(4α)-Kaurane-17,18-dioic acid

Name: (4α)-Kaurane-17,18-dioic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Others
Catalog number	BBF-05469
CAS	58648-80-9
Molecular Weight	334.45
Molecular Formula	C20H30O4

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4 R&D and scale-up labs

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Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

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Synonyms	Kaurane-17,18-dioic acid, (4α)-; Kaurane-17,18-dioic acid, (4alpha)-
IUPAC Name	(4R,4aS,6aS,8S,9R,11aR,11bS)-4,11b-dimethyltetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4,8-dicarboxylic acid

1. Five new ent-kaurane diterpenes from Annona squamosa L. pericarps

Ya-Yun Chen, Cheng-Yao Ma, Mao-Lin Wang, Jia-Hui Lu, Peng Hu, Jian-Wei Chen, Xiang Li, Yong Chen Nat Prod Res. 2020 Aug;34(15):2243-2247. doi: 10.1080/14786419.2019.1582048. Epub 2019 Mar 5.

In the present study, five new ent-kaurane diterpenes including 4α-hydroxy-17,19-dinor-ent-kaurane-16-one (1), 4β-hydroxy-16β-H-18-nor-ent-kaurane-17-oic acid (2), 4β,17-dihydroxy-16α-acetoxy-18-nor-ent-kaurane (3), Annosquamosin Z (4) and 16α-H-ent-kaurane-17,18-dioic acid, 17-methy ester (5) were isolated from Annona squamosa L. pericarp. The compounds were also evaluated for their cytotoxic activities against SMMC-7721 and HepG2 cell lines, among which compound 3 exhibited potent cytotoxicity with IC50 value of less than 20 μM.

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(4α)-Kaurane-17,18-dioic acid

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