5,6-Dimethoxy-3H-isobenzofuran-1-one
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| Category | Others |
| Catalog number | BBF-05436 |
| CAS | 531-88-4 |
| Molecular Weight | 194.18 |
| Molecular Formula | C10H10O4 |
| Purity | >90% |
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Description
5,6-Dimethoxy-3H-isobenzofuran-1-one is a useful adjunct in the detection of illicit opiate in the management of substance misuses.
Specification
| Related CAS | 759409-69-3 (ion(1-)) |
| Synonyms | 5,6-dimethoxyisobenzofuran-1(3H)-one; Isobenzofuranone, 5,6-dimethoxy-1(3H)-; NSC 25379; 5,6-Dimethoxyphthalide; Macconine; Meconinm; m-Meconin; meta-Meconine |
| Storage | Store at 2-8°C |
| IUPAC Name | 5,6-dimethoxy-3H-2-benzofuran-1-one |
| Canonical SMILES | COC1=C(C=C2C(=C1)COC2=O)OC |
| InChI | InChI=1S/C10H10O4/c1-12-8-3-6-5-14-10(11)7(6)4-9(8)13-2/h3-4H,5H2,1-2H3 |
| InChI Key | UKFAWRZYFYOXEG-UHFFFAOYSA-N |
Properties
| Appearance | Pale Yellow Solid |
| Boiling Point | 403.0±45.0°C (Predicted) |
| Melting Point | 155-157°C |
| Density | 1.260±0.06 g/cm3 (Predicted) |
| Solubility | Soluble in Chloroform, Ethyl Acetate |
Reference Reading
1. 3-Heptylidene-4,6-Dimethoxy-3 H-Isobenzofuran-1-One Is Genotoxic, Increases the Frequency of Cell Death, and Potentiates the Effects of Cyclophosphamide and Cisplatin
Silvia Cordeiro das Neves, Flavio Henrique de Araújo, et al. Molecules. 2023 Jan 20;28(3):1044. doi: 10.3390/molecules28031044.
3-heptylidene-4,6-dimethoxy-3H-isobenzofuran-1-one (Phthalide 1) is the precursor of three resorcinol lipids that have been described as potential chemotherapeutic agents and capable of potentiating the effects of cyclophosphamide. In this study, we evaluated the genotoxic potential, cell-killing potential, and interactions with cyclophosphamide and cisplatin of phthalide 1. Twelve groups were created from 120 mice: Negative Control, cyclophosphamide (100 mg/kg), cisplatin (6 mg/kg), Phthalide 1 (5, 10 and 20 mg/kg), and associations of 1 with cyclophosphamide and 1 with cisplatin. The results demonstrate that 1 increases (p < 0.05) the frequency of chromosomal damage, liver and kidney cell death, and splenic phagocytosis. The association of 1 with cyclophosphamide and cisplatin demonstrated a chemopreventive effect and, therefore, a reduction (p < 0.05) in the frequency of chromosomal damage. However, cell death and splenic phagocytosis did not suffer significant variations. As a result of the above, 1 has potential chemotherapeutic application and may be a candidate for developing a new generation of chemotherapeutics. In addition, it has characteristics to be used as a chemotherapy adjuvant in association with cyclophosphamide and cisplatin since it increases the frequency of cell death induced by chemotherapy. We also reported that the chemopreventive effect of 1, in association with cyclophosphamide and cisplatin, can prevent adverse effects (induction of DNA damage in non-tumor cells) without interfering with the mode of action of chemotherapy drugs and, therefore, without reducing the induction of cell death.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
