A-500359 M-1
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Category | Antibiotics |
Catalog number | BBF-03180 |
CAS | |
Molecular Weight | 635.66 |
Molecular Formula | C23H33N5O12S2 |
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Description
A-500359 M-1 is a bacterial translocase-1 (Translocase I, EC 2.7. 8.13) inhibitor produced by Streptomyces griseus SANK 60196. It has activity against Mycobacterium smegmatis, Streptococcus pneumoniae and Streptococcus pyogenes, with an MIC of 6.25-12.5 µg/mL.
Specification
Synonyms | N-[2-({2-[(6-{[(2S,3S,4R,5R)-5-(2,4-Dioxo(1,3-dihydropyrimidinyl))-4-hydroxy-3-methoxyoxolan-2-yl]carbamoylmethoxy}(4S,5S,6S)-4,5-dihydroxy-4H-5,6-dihydropyran-2-yl)carbonylamino]ethyl}disulfanyl)ethyl]acetamide |
IUPAC Name | (2S,3S,4S)-N-[2-(2-acetamidoethyldisulfanyl)ethyl]-2-[(1R)-2-amino-1-[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-3-methoxyoxolan-2-yl]-2-oxoethoxy]-3,4-dihydroxy-3,4-dihydro-2H-pyran-6-carboxamide |
Canonical SMILES | CC(=O)NCCSSCCNC(=O)C1=CC(C(C(O1)OC(C2C(C(C(O2)N3C=CC(=O)NC3=O)O)OC)C(=O)N)O)O |
InChI | InChI=1S/C23H33N5O12S2/c1-10(29)25-4-7-41-42-8-5-26-20(35)12-9-11(30)14(32)22(38-12)40-18(19(24)34)17-16(37-2)15(33)21(39-17)28-6-3-13(31)27-23(28)36/h3,6,9,11,14-18,21-22,30,32-33H,4-5,7-8H2,1-2H3,(H2,24,34)(H,25,29)(H,26,35)(H,27,31,36)/t11-,14-,15+,16-,17-,18+,21+,22+/m0/s1 |
InChI Key | ZUCKJVVXVVOESY-KQSVRIFWSA-N |
Properties
Antibiotic Activity Spectrum | Gram-positive bacteria; mycobacteria |
Density | 1.6±0.1 g/cm3 |
Reference Reading
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2