A 54556A
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| Category | Antibiotics |
| Catalog number | BBF-04205 |
| CAS | 95398-45-1 |
| Molecular Weight | 718.84 |
| Molecular Formula | C38H50N6O8 |
| Purity | >95% by HPLC |
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Description
A 54556A is an unusual depsipeptide antibiotic produced by the strain of streptomyces hawaiiensis. It can inhibit the growth of 786-O, 769-P and ACHN renal carcinoma cells in MTT assay. A 54556A may be a potential chemotherapeutic agent for treatment of renal carcinoma. It has potent activity against gram-positive and gram-negative bacteria, including MRSA.
Specification
| Synonyms | Antibiotic A 54556A; A 54556 factor A; ADEP 1; Acyldepsipeptide 1; Acyldepsipeptide A; N-[[(2E,4E,6E)-1-Oxo-2,4,6-octatrienyl]-L-Phe-]cyclo[L-Ser*-L-Pro-N-methyl-L-Ala-L-Ala-4beta-methyl-L-Pro-] |
| Storage | Store at 2-8°C |
| IUPAC Name | (2E,4E,6E)-N-[(2S)-1-oxo-3-phenyl-1-[[(3S,7S,9R,13S,16S,19S)-9,13,16,17-tetramethyl-2,6,12,15,18-pentaoxo-5-oxa-1,11,14,17-tetrazatricyclo[17.3.0.07,11]docosan-3-yl]amino]propan-2-yl]octa-2,4,6-trienamide |
| Canonical SMILES | CC=CC=CC=CC(=O)NC(CC1=CC=CC=C1)C(=O)NC2COC(=O)C3CC(CN3C(=O)C(NC(=O)C(N(C(=O)C4CCCN4C2=O)C)C)C)C |
| InChI | InChI=1S/C38H50N6O8/c1-6-7-8-9-13-18-32(45)40-28(21-27-15-11-10-12-16-27)34(47)41-29-23-52-38(51)31-20-24(2)22-44(31)35(48)25(3)39-33(46)26(4)42(5)37(50)30-17-14-19-43(30)36(29)49/h6-13,15-16,18,24-26,28-31H,14,17,19-23H2,1-5H3,(H,39,46)(H,40,45)(H,41,47)/b7-6+,9-8+,18-13+/t24-,25+,26+,28+,29+,30+,31+/m1/s1 |
| InChI Key | ZGRSXMWWGUOTAO-VIEJTCJKSA-N |
| Source | Streptomyces sp. |
Properties
| Appearance | Pale Yellow to Light Brown Solid |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria |
| Boiling Point | 1086.9±65.0°C at 760 mmHg |
| Melting Point | >180°C (dec.) |
| Density | 1.3±0.1 g/cm3 |
| Solubility | Slightly soluble in Chloroform, DMSO, Methanol |
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
