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A-72363 A1

Name: A-72363 A1
Brand: BOC Sciences
Rating: 5 (1 reviews)

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category	Enzyme inhibitors
Catalog number	BBF-03163
CAS
Molecular Weight	218.21
Molecular Formula	C8H14N2O5

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Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

A-72363 A1 is a Heparanase inhibitor produced by Streptomyces nobilis SANK 60192.

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Synonyms	A-72363 A-1; 4alpha,5beta-Dihydroxy-6beta-(acetylamino)piperidine-3alpha-carboxylic acid
IUPAC Name	(3S,4S,5S,6R)-6-acetamido-4,5-dihydroxypiperidine-3-carboxylic acid
Canonical SMILES	CC(=O)NC1C(C(C(CN1)C(=O)O)O)O
InChI	InChI=1S/C8H14N2O5/c1-3(11)10-7-6(13)5(12)4(2-9-7)8(14)15/h4-7,9,12-13H,2H2,1H3,(H,10,11)(H,14,15)/t4-,5-,6+,7+/m0/s1
InChI Key	DQTKLICLJUKNCG-VWDOSNQTSA-N

Appearance	White Powder
Boiling Point	579.2±50.0°C at 760 mmHg
Density	1.5±0.1 g/cm3
Solubility	Soluble in Water

1. A-72363 A-1, A-2, and C, novel heparanase inhibitors from Streptomyces nobilis SANK 60192, II. Biological activities

Y Kawase, M Takahashi, T Takatsu, M Arai, M Nakajima, K Tanzawa J Antibiot (Tokyo). 1996 Jan;49(1):61-4. doi: 10.7164/antibiotics.49.61.

Inhibitory activities of A-72363 A-1, A-2 and C, the diastereomers of a neuraminidase inhibitor siastatin B, against various glycosidases were tested in comparison to siastatin B. Despite these compounds differing only in their configuration, each compound showed strikingly different specificities towards the various glycosidases tested. A-72363 C inhibited bovine liver beta-glucuronidase and tumor cell heparanase with IC50 values of 1.6 microM and 12 microM, respectively.

2. A-72363 A-1, A-2 and C, novel heparanase inhibitors from Streptomyces nobilis SANK 60192. I. Taxonomy of producing organism, fermentation, isolation and structure elucidation

T Takatsu, M Takahashi, Y Kawase, R Enokita, T Okazaki, H Matsukawa, K Ogawa, Y Sakaida, T Kagasaki, T Kinoshita, M Nakajima, K Tanzawa J Antibiot (Tokyo). 1996 Jan;49(1):54-60. doi: 10.7164/antibiotics.49.54.

Novel heparanse inhibitors, A72363 A-1, A-2, and C, were isolated from the culture filtrate of Streptomyces nobilis SANK 60192 by column chromatography on various resinous adsorbents, followed by preparative anion exchange HPLC. Spectroscopic studies revealed that they are diastereomers of siastatin B, a neuraminidase inhibitor.

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A-72363 A1

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