Email:
 Phone:
Get A Quote

A-72363 A1

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category Enzyme inhibitors
Catalog number BBF-03163
CAS
Molecular Weight 218.21
Molecular Formula C8H14N2O5

Online Inquiry

Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

A-72363 A1 is a Heparanase inhibitor produced by Streptomyces nobilis SANK 60192.

  • Specification
  • Properties
  • Reference Reading
  • Price Product List
Synonyms A-72363 A-1; 4alpha,5beta-Dihydroxy-6beta-(acetylamino)piperidine-3alpha-carboxylic acid
IUPAC Name (3S,4S,5S,6R)-6-acetamido-4,5-dihydroxypiperidine-3-carboxylic acid
Canonical SMILES CC(=O)NC1C(C(C(CN1)C(=O)O)O)O
InChI InChI=1S/C8H14N2O5/c1-3(11)10-7-6(13)5(12)4(2-9-7)8(14)15/h4-7,9,12-13H,2H2,1H3,(H,10,11)(H,14,15)/t4-,5-,6+,7+/m0/s1
InChI Key DQTKLICLJUKNCG-VWDOSNQTSA-N
Appearance White Powder
Boiling Point 579.2±50.0°C at 760 mmHg
Density 1.5±0.1 g/cm3
Solubility Soluble in Water
1. A-72363 A-1, A-2, and C, novel heparanase inhibitors from Streptomyces nobilis SANK 60192, II. Biological activities
Y Kawase, M Takahashi, T Takatsu, M Arai, M Nakajima, K Tanzawa J Antibiot (Tokyo). 1996 Jan;49(1):61-4. doi: 10.7164/antibiotics.49.61.
Inhibitory activities of A-72363 A-1, A-2 and C, the diastereomers of a neuraminidase inhibitor siastatin B, against various glycosidases were tested in comparison to siastatin B. Despite these compounds differing only in their configuration, each compound showed strikingly different specificities towards the various glycosidases tested. A-72363 C inhibited bovine liver beta-glucuronidase and tumor cell heparanase with IC50 values of 1.6 microM and 12 microM, respectively.
2. A-72363 A-1, A-2 and C, novel heparanase inhibitors from Streptomyces nobilis SANK 60192. I. Taxonomy of producing organism, fermentation, isolation and structure elucidation
T Takatsu, M Takahashi, Y Kawase, R Enokita, T Okazaki, H Matsukawa, K Ogawa, Y Sakaida, T Kagasaki, T Kinoshita, M Nakajima, K Tanzawa J Antibiot (Tokyo). 1996 Jan;49(1):54-60. doi: 10.7164/antibiotics.49.54.
Novel heparanse inhibitors, A72363 A-1, A-2, and C, were isolated from the culture filtrate of Streptomyces nobilis SANK 60192 by column chromatography on various resinous adsorbents, followed by preparative anion exchange HPLC. Spectroscopic studies revealed that they are diastereomers of siastatin B, a neuraminidase inhibitor.

Bio Calculators

  • Solution Dilution Calculator
  • Molecular Weight Calculator
  • Molarity Calculator
Stock concentration: *
Desired final volume: *
Desired concentration: *

L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

Calculate
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
g/mol
g

Recently viewed products

A-72363 A1

Online Inquiry

USA

  • International : 
    US & Canada (Toll free):
  • Fax:
  • Email:

UK

  • Tel:
  • Email:

Copyright © 2025 BOC Sciences. All rights reserved.

cartIcon
Inquiry Basket
Loading ......
Delete selectedGo to checkout