A-75943
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| Category | Enzyme inhibitors |
| Catalog number | BBF-03166 |
| CAS | 201215-10-3 |
| Molecular Weight | 281.35 |
| Molecular Formula | C15H23NO4 |
| Purity | >98% |
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Description
A-75943 is is a bone resorption inhibitor produced by Streptomyces sp. SANK61296. In vitro tests, it has the effect of inhibiting bone resorption with IC50 of 0.35 µmol/L. It also inhibits the bone resorption in rats with thyroid and parathyroidectomy.
Specification
| Synonyms | 2H-Pyran-4-acetamide, 2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)tetrahydro-6-oxo-, (2R,4S)- |
| Storage | Store at -20°C |
| IUPAC Name | 2-[(2R,4S)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-6-oxooxan-4-yl]acetamide |
| Canonical SMILES | CC1CC(C(=O)C(C1)C2CC(CC(=O)O2)CC(=O)N)C |
| InChI | InChI=1S/C15H23NO4/c1-8-3-9(2)15(19)11(4-8)12-5-10(6-13(16)17)7-14(18)20-12/h8-12H,3-7H2,1-2H3,(H2,16,17)/t8-,9-,10-,11-,12+/m0/s1 |
| InChI Key | SAVFIMRLAWCZGX-UHFZAUJKSA-N |
Properties
| Appearance | Colorless Powder |
| Boiling Point | 533.8±25.0°C at 760 mmHg |
| Density | 1.1±0.1 g/cm3 |
| Solubility | Soluble in DMSO |
Reference Reading
1. A novel bone resorption inhibitor, A-75943 isolated from Streptomyces sp. SANK 61296
T Morishita, A Sato, T Ando, K Oizumi, M Miyamoto, R Enokita, T Okazaki J Antibiot (Tokyo). 1998 Jun;51(6):531-8. doi: 10.7164/antibiotics.51.531.
A novel bone resorption inhibitor, A-75943, was isolated from Streptomyces sp. SANK 61296. Its structure was determined to be (1"S,2'R,3"S,4S',5"S)-2-[(3",5"- dimethyl-2"-oxocyclohexan-1"-yl)-6'-oxotetrahydropyran-4'-yl ]acetamide by spectral analyses and chemical conversion of cycloheximide. A-75943 inhibited bone resorption in vitro in a concentration-dependent manner with an IC50 of 0.35 microM, and also displayed an inhibitory effect on bone resorption in thyroid and parathyroid-extracted rats.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
