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Actinopyrone B

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Actinopyrone B
Category Antibiotics
Catalog number BBF-00546
CAS 88378-60-3
Molecular Weight 386.52
Molecular Formula C24H34O4
Purity 95%

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Actinopyrone B is an antibiotic isolated from Streptomyces pacttm. Actinopyrone has a relaxing effect on the coronary blood vessels of anesthetized dogs, and has weak anti-gram-positive bacteria and trichoderma activity.

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Synonyms 4H-Pyran-4-one, 2-(10-hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraenyl)-6-methoxy-3-methyl-
IUPAC Name 2-[(2E,5E,7E,11E)-10-hydroxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraenyl]-6-methoxy-3-methylpyran-4-one
Canonical SMILES CC=C(C)C(C(C)C=C(C)C=CCC(=CCC1=C(C(=O)C=C(O1)OC)C)C)O
InChI InChI=1S/C24H34O4/c1-8-18(4)24(26)19(5)14-17(3)11-9-10-16(2)12-13-22-20(6)21(25)15-23(27-7)28-22/h8-9,11-12,14-15,19,24,26H,10,13H2,1-7H3/b11-9+,16-12+,17-14+,18-8+
InChI Key VKAOERDMNZUNBK-AUTRRBDOSA-N
Appearance Colorless Oil
Antibiotic Activity Spectrum Gram-positive bacteria; fungi
1. Actinopyrones A, B and C, new physiologically active substances. II. Physico-chemical properties and chemical structures
K Yano, K Yokoi, J Sato, J Oono, T Kouda, Y Ogawa, T Nakashima J Antibiot (Tokyo). 1986 Jan;39(1):38-43. doi: 10.7164/antibiotics.39.38.
The structure of physiologically active substances, actinopyrones A, B and C, produced by Streptomyces pactum S12538 were determined on the basis of their spectral and chemical character. These substances were structurally related to piericidin A1.
2. Actinopyrones A, B and C, new physiologically active substances. I. Producing organism, fermentation, isolation and biological properties
K Yano, K Yokoi, J Sato, J Oono, T Kouda, Y Ogawa, T Nakashima J Antibiot (Tokyo). 1986 Jan;39(1):32-7. doi: 10.7164/antibiotics.39.32.
A strain of Streptomyces was found to produce new physiologically active substances. The active compounds were purified and separated into three substances named actinopyrones A, B and C. Actinopyrones exhibited coronary vasodilating activities in anesthetized dogs and weakly antimicrobial activities against some Gram-positive bacteria and dermatophytes.

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