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Actinopyrone C

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Actinopyrone C
Category Antibiotics
Catalog number BBF-00547
CAS 88378-61-4
Molecular Weight 414.58
Molecular Formula C26H38O4
Purity 95%

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Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

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Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Actinopyrone C is an antibiotic isolated from Streptomyces pacttm. Actinopyrone has a relaxing effect on the coronary blood vessels of anesthetized dogs, and has weak anti-gram-positive bacteria and trichoderma activity.

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Synonyms 4H-Pyran-4-one, 3-ethyl-6-(10-hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraenyl)-2-methoxy-5-methyl-
IUPAC Name 5-ethyl-2-[(2E,5E,7E,11E)-10-hydroxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraenyl]-6-methoxy-3-methylpyran-4-one
Canonical SMILES CCC1=C(OC(=C(C1=O)C)CC=C(C)CC=CC(=CC(C)C(C(=CC)C)O)C)OC
InChI InChI=1S/C26H38O4/c1-9-19(5)24(27)20(6)16-18(4)13-11-12-17(3)14-15-23-21(7)25(28)22(10-2)26(29-8)30-23/h9,11,13-14,16,20,24,27H,10,12,15H2,1-8H3/b13-11+,17-14+,18-16+,19-9+
InChI Key KARZXNDNDLSNJC-NFDXLUQOSA-N
Appearance Colorless Oil
Antibiotic Activity Spectrum Gram-positive bacteria; fungi
Boiling Point 580.5°C at 760 mmHg
Density 1.03 g/cm3
1. Actinopyrones A, B and C, new physiologically active substances. II. Physico-chemical properties and chemical structures
K Yano, K Yokoi, J Sato, J Oono, T Kouda, Y Ogawa, T Nakashima J Antibiot (Tokyo). 1986 Jan;39(1):38-43. doi: 10.7164/antibiotics.39.38.
The structure of physiologically active substances, actinopyrones A, B and C, produced by Streptomyces pactum S12538 were determined on the basis of their spectral and chemical character. These substances were structurally related to piericidin A1.
2. Actinopyrones A, B and C, new physiologically active substances. I. Producing organism, fermentation, isolation and biological properties
K Yano, K Yokoi, J Sato, J Oono, T Kouda, Y Ogawa, T Nakashima J Antibiot (Tokyo). 1986 Jan;39(1):32-7. doi: 10.7164/antibiotics.39.32.
A strain of Streptomyces was found to produce new physiologically active substances. The active compounds were purified and separated into three substances named actinopyrones A, B and C. Actinopyrones exhibited coronary vasodilating activities in anesthetized dogs and weakly antimicrobial activities against some Gram-positive bacteria and dermatophytes.

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