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Adipostatin B

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category Antibiotics
Catalog number BBF-00039
CAS 144284-17-3
Molecular Weight 320.51
Molecular Formula C21H36O2

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Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Adipostatin is a glycerol-3-phosphate dehydrogenase inhibitor produced in Streptornyces cyaneus 2299-SVI. Adipostatin B is an inhibitor of glycerol-3-phosphate dehydrogenase.

  • Specification
  • Properties
  • Reference Reading
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Synonyms 5-Isopentadecylresorcinol; 5-n-isopentadecylresorcinol
IUPAC Name 5-(13-methyltetradecyl)benzene-1,3-diol
Canonical SMILES CC(C)CCCCCCCCCCCCC1=CC(=CC(=C1)O)O
InChI InChI=1S/C21H36O2/c1-18(2)13-11-9-7-5-3-4-6-8-10-12-14-19-15-20(22)17-21(23)16-19/h15-18,22-23H,3-14H2,1-2H3
InChI Key AYZBMIJCGJIGNK-UHFFFAOYSA-N
Appearance White Powder
Boiling Point 448.1°C at 760 mmHg
Melting Point 90-91°C
Density 0.959 g/cm3
1. Adipostatins A and B, new inhibitors of glycerol-3-phosphate dehydrogenase
N Tsuge, M Mizokami, S Imai, A Shimazu, H Seto J Antibiot (Tokyo). 1992 Jun;45(6):886-91. doi: 10.7164/antibiotics.45.886.
As a result of screening for inhibitors of glycerol-3-phosphate dehydrogenase, which may be effective to prevent corpulence, we isolated two inhibitors named adipostatin A and adipostatin B from the culture broth of Streptomyces cyaneus 2299-SV1. Their structures have been established to be 5-n-pentadecylresorcinol and 5-isopentadecylresorcinol, respectively. Adipostatin A and adipostatin B inhibited glycerol-3-phosphate dehydrogenase at the IC50 values of 4.1 microM and 4.5 microM, respectively. These compounds prevented triglyceride accumulation in 3T3-L1 cells at a concentration of the microM level.

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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