Adipostatin B
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| Category | Antibiotics |
| Catalog number | BBF-00039 |
| CAS | 144284-17-3 |
| Molecular Weight | 320.51 |
| Molecular Formula | C21H36O2 |
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Description
Adipostatin is a glycerol-3-phosphate dehydrogenase inhibitor produced in Streptornyces cyaneus 2299-SVI. Adipostatin B is an inhibitor of glycerol-3-phosphate dehydrogenase.
Specification
| Synonyms | 5-Isopentadecylresorcinol; 5-n-isopentadecylresorcinol |
| IUPAC Name | 5-(13-methyltetradecyl)benzene-1,3-diol |
| Canonical SMILES | CC(C)CCCCCCCCCCCCC1=CC(=CC(=C1)O)O |
| InChI | InChI=1S/C21H36O2/c1-18(2)13-11-9-7-5-3-4-6-8-10-12-14-19-15-20(22)17-21(23)16-19/h15-18,22-23H,3-14H2,1-2H3 |
| InChI Key | AYZBMIJCGJIGNK-UHFFFAOYSA-N |
Properties
| Appearance | White Powder |
| Boiling Point | 448.1°C at 760 mmHg |
| Melting Point | 90-91°C |
| Density | 0.959 g/cm3 |
Reference Reading
1. Adipostatins A and B, new inhibitors of glycerol-3-phosphate dehydrogenase
N Tsuge, M Mizokami, S Imai, A Shimazu, H Seto J Antibiot (Tokyo). 1992 Jun;45(6):886-91. doi: 10.7164/antibiotics.45.886.
As a result of screening for inhibitors of glycerol-3-phosphate dehydrogenase, which may be effective to prevent corpulence, we isolated two inhibitors named adipostatin A and adipostatin B from the culture broth of Streptomyces cyaneus 2299-SV1. Their structures have been established to be 5-n-pentadecylresorcinol and 5-isopentadecylresorcinol, respectively. Adipostatin A and adipostatin B inhibited glycerol-3-phosphate dehydrogenase at the IC50 values of 4.1 microM and 4.5 microM, respectively. These compounds prevented triglyceride accumulation in 3T3-L1 cells at a concentration of the microM level.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
