Adustin
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| Category | Antibiotics |
| Catalog number | BBF-00042 |
| CAS | 69579-74-4 |
| Molecular Weight | 188.18 |
| Molecular Formula | C11H8O3 |
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Description
Akrabicin is an antibiotic produced in Streptomyces galactis against yeast and tinea mold.
Specification
| Synonyms | (3-Hydroxy-2-furanyl)phenylmethanone; Methanone, (3-hydroxy-2-furanyl)phenyl-; (2E)-2-[hydroxy(phenyl)methylidene]furan-3-one; 2-Benzoyl-3-hydroxyfuran |
| IUPAC Name | (3-hydroxyfuran-2-yl)-phenylmethanone |
| Canonical SMILES | C1=CC=C(C=C1)C(=O)C2=C(C=CO2)O |
| InChI | InChI=1S/C11H8O3/c12-9-6-7-14-11(9)10(13)8-4-2-1-3-5-8/h1-7,12H |
| InChI Key | RAFAVNTVTXJMAQ-UHFFFAOYSA-N |
Properties
| Appearance | Colorless long needle Crystal |
| Antibiotic Activity Spectrum | fungi; yeast |
| Boiling Point | 393°C at 760 mmHg |
| Melting Point | 62.5-63.5°C |
| Density | 1.361 g/cm3 |
Reference Reading
1. Laboratory models of post-traumatic stress disorder: The elusive bridge to translation
Joseph E Dunsmoor, Josh M Cisler, Gregory A Fonzo, Suzannah K Creech, Charles B Nemeroff Neuron. 2022 Jun 1;110(11):1754-1776. doi: 10.1016/j.neuron.2022.03.001. Epub 2022 Mar 23.
Post-traumatic stress disorder (PTSD) is a debilitating mental illness composed of a heterogeneous collection of symptom clusters. The unique nature of PTSD as arising from a precipitating traumatic event helps simplify cross-species translational research modeling the neurobehavioral effects of stress and fear. However, the neurobiological progress on these complex neural circuits informed by animal models has yet to produce novel, evidence-based clinical treatment for PTSD. Here, we provide a comprehensive overview of popular laboratory models of PTSD and provide concrete ideas for improving the validity and clinical translational value of basic research efforts in humans. We detail modifications to simplified animal paradigms to account for myriad cognitive factors affected in PTSD, which may contribute to abnormalities in regulating fear. We further describe new avenues for integrating different areas of psychological research underserved by animal models of PTSD. This includes incorporating emerging trends in the cognitive neuroscience of episodic memory, emotion regulation, social-emotional processes, and PTSD subtyping to provide a more comprehensive recapitulation of the human experience to trauma in laboratory research.
2. DDX18 prevents R-loop-induced DNA damage and genome instability via PARP-1
Wen-Ling Lin, Jung-Kuei Chen, Xuemei Wen, Wei He, Geovanny A Zarceno, Yutian Chen, Shi Chen, Tanya T Paull, Hung-Wen Liu Cell Rep. 2022 Jul 19;40(3):111089. doi: 10.1016/j.celrep.2022.111089.
R loops occur frequently in genomes and contribute to fundamental biological processes at multiple levels. Consequently, understanding the molecular and cellular biology of R loops has become an emerging area of research. Here, it is shown that poly(ADP-ribose) polymerase-1 (PARP-1) can mediate the association of DDX18, a putative RNA helicase, with R loops thereby modulating R-loop homeostasis in endogenous R-loop-prone and DNA lesion regions. DDX18 depletion results in aberrant endogenous R-loop accumulation, which leads to DNA-replication defects. In addition, DDX18 depletion renders cells more sensitive to DNA-damaging agents and reduces RPA32 and RAD51 foci formation in response to irradiation. Notably, DDX18 depletion leads to γH2AX accumulation and genome instability, and RNase H1 overexpression rescues all the DNA-repair defects caused by DDX18 depletion. Taken together, these studies uncover a function of DDX18 in R-loop-mediated events and suggest a role for PARP-1 in mediating the binding of specific DDX-family proteins with R loops in cells.
3. Validation of the FRESH Austin food frequency questionnaire using multiple 24-h dietary recalls
Christine Es Jovanovic, Jacob Whitefield, Deanna M Hoelscher, Boajiang Chen, Nalini Ranjit, Alexandra E van den Berg Public Health Nutr. 2022 Jun;25(6):1586-1594. doi: 10.1017/S1368980021002214. Epub 2021 May 26.
Objective: The purpose of the current study was to examine the validity of an FFQ utilised in the Food Retail: Evaluating Strategies for a Healthy Austin (FRESH Austin) study, designed to evaluate changes in the consumption of fruits and vegetables (FV) in diverse low-income communities in Austin, TX. Design: The FRESH Austin FFQ was validated against three 24-h dietary recalls (24hDR). All dietary assessments were administered (in-person or by telephone) by trained investigators. Setting: Recruitment was conducted at sites within the geographic areas targeted in the FRESH Austin recruitment. People at a community health clinic, a local health centre and a YMCA within the intervention area were approached by trained and certified data collectors, and invited to participate. Participants: Among fifty-six participants, 83 % were female, 46 % were non-White, 24 % had income < $25 K/year and 30 % spoke only/mostly Spanish at home. Results: The FFQ and average of three 24hDR produce similar estimates of average total servings/d across FV (6·68 and 6·40 servings/d, respectively). Correlations produced measures from 0·01 for 'Potatoes' and 0·59 for 'Other Vegetables'. Mean absolute percentage errors values were small for all FV, suggesting the variance of the error estimates was also small. Bland-Altman plots indicate acceptable levels of agreement between the two methods. Conclusion: These outcomes indicate that the FRESH FFQ is a valid instrument for assessing FV consumption. The validation of the FRESH Austin FFQ provides important insights for evaluating community-based efforts to increase FV consumption in diverse populations.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
