Adxanthromycin A
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| Category | Enzyme inhibitors |
| Catalog number | BBF-00040 |
| CAS | |
| Molecular Weight | 816.76 |
| Molecular Formula | C42H40O17 |
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Description
Adxanthromycin A, a new inhibitor of ICAM-1/LFA-1 mediated cell adhesion from Streptomyces sp. NA-148.
Properties
| Appearance | Light Yellow Powder |
Reference Reading
1. Adxanthromycins A and B, new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule from Streptomyces sp. NA-148. I. Taxonomy, production, isolation and biological activities
T Nakano, T Koiwa, S Takahashi, A Nakagawa J Antibiot (Tokyo). 2000 Jan;53(1):12-8. doi: 10.7164/antibiotics.53.12.
Two new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule, adxanthromycins A and B were isolated from the cultured broth of a streptomycete strain. The strain was identified as Streptomyces sp. NA-148 from its morphological and physiological characteristics. Adxanthromycins A and B inhibited the formation of the JY cell aggregates from 1.5 microg/ml, respectively, in a dose dependent manner. Components A and B also inhibited a human T cell leukemia cell line SKW-3 adhesion to soluble ICAM-1 in a dose-dependent manner with an IC50 of 18.8 microg/ml and 25.0 microg/ml, respectively.
2. Adxanthromycins A and B, new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule from Streptomyces sp. NA-148. II. Physico-chemical properties and structure elucidation
S Takahashi, T Nakano, T Koiwa, T Noshita, S Funayama, H Koshino, A Nakagawa J Antibiot (Tokyo). 2000 Feb;53(2):163-70. doi: 10.7164/antibiotics.53.163.
Adxanthromycins A and B are new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule isolated from the fermentation broth of Streptomyces sp. NA-148. The molecular formula of adxanthromycins A and B were determined as C42H40O17 and C48H50O22, respectively by FAB-MS and NMR spectral analyses, and the structures of both compounds were elucidated to be a dimeric anthrone peroxide skeleton containing alpha-D-galactose by various NMR spectral analyses and chemical degradation.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
