Agrocybin

Agrocybin

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Agrocybin
Category Antibiotics
Catalog number BBF-00657
CAS 544-44-5
Molecular Weight 147.13
Molecular Formula C8H5NO2
Purity 97%

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Description

It is produced by the strain of Agrocybe dura. It has the activity of anti-gram-positive bacteria, negative bacteria, mycobacterium and mildew, which is unstable and easy to be inactivated.

Specification

Synonyms 8-Hydroxy-2,4,6-octatriynamide; A0AFV4JUIT; NSC636326; BRN 1761957; 2,4,6-OCTATRIYNAMIDE, 8-HYDROXY-; SCHEMBL1654320; CHEMBL1967731; CTK8J1637; DTXSID20202786; ZINC5722724; LMFA08010027; AKOS006341004; NSC-63632
Storage RT
IUPAC Name 8-hydroxyocta-2,4,6-triynamide
Canonical SMILES C(C#CC#CC#CC(=O)N)O
InChI InChI=1S/C8H5NO2/c9-8(11)6-4-2-1-3-5-7-10/h10H,7H2,(H2,9,11)
InChI Key OXONWCQUZYDTNF-UHFFFAOYSA-N

Properties

Appearance Crystalline Powder
Antibiotic Activity Spectrum Gram-positive bacteria; Gram-negative bacteria; mycobacteria; fungi
Boiling Point 321.2 °C at 760 mmHg
Melting Point 130-140 °C (dec.)
Density 1.352 g/cm3
Solubility Soluble in Ethanol

Reference Reading

1. Anti-Aging Effect of Agrocybe aegerita Polysaccharide through Regulation of Oxidative Stress and Gut Microbiota
Xiaoyan Liu, Linxiu Wu, Aijun Tong, Hongmin Zhen, Dong Han, Hongyang Yuan, Fannian Li, Chengtao Wang, Guangsen Fan Foods. 2022 Nov 24;11(23):3783. doi: 10.3390/foods11233783.
Polysaccharides extracted from Agrocybe aegerita (AAPS) have various physiological effects. In this study, we used the naturally aging Drosophila melanogaster and D-galactose-induced aging mice as animal models to study the anti-aging effects of AAPS via the alleviation of oxidative stress and regulation of gut microbiota. Results showed that AAPS could significantly prolong lifespan and alleviate oxidative stress induced by H2O2 of Drosophila melanogaster. In addition, AAPS significantly increased the activities of antioxidant enzymes in Drosophila melanogaster and mice, and reduced the content of MDA. Furthermore, AAPS reshaped the disordered intestinal flora, increased the abundance ratio of Firmicutes to Bacteroidetes, and increased the abundance of beneficial bacteria Lactobacillus. Our results demonstrated that AAPS had good antioxidant and potential anti-aging effects in vivo.
2. Polysaccharide from Agrocybe cylindracea prevents diet-induced obesity through inhibiting inflammation mediated by gut microbiota and associated metabolites
Zhenjun Zhu, Rui Huang, Aohuan Huang, Juan Wang, Wei Liu, Shujian Wu, Mengfei Chen, Moutong Chen, Yizhen Xie, Chunwei Jiao, Jumei Zhang, Qingping Wu, Yu Ding Int J Biol Macromol. 2022 Jun 1;209(Pt A):1430-1438. doi: 10.1016/j.ijbiomac.2022.04.107. Epub 2022 Apr 21.
Polysaccharide from Agrocybe cylindracea (ACP) has been demonstrated with various health benefits, but its anti-obesity effect and underlying mechanisms remain poorly understood. This study aimed to investigate the beneficial effects of ACP in high-fat diet (HFD)-induced obese mice by targeting gut microbiota and metabolites. 9-week ACP supplementation in HFD-fed mice reduced body weight, adipose accumulation, impaired insulin resistance, lipid levels, and liver injuries, which were negatively correlated to the pro-inflammatory factors, particularly tumor necrosis factor-alpha (TNF-α) and interleukin- 6 (IL-6). Moreover, ACP not only restored HFD-induced gut disorder, as indicated by the depletion of Desulfovibrio and Oscillibacter and the enrichment of the Bacteroides, Parabacteroides, Butyricimonas, and Dubosiella, but also positively regulated gut metabolites such as solavetivone and N-acetylneuraminic acid. Spearman's correlation analysis revealed that the ACP-altered microbes and metabolites were highly correlated with inflammation-related indexes. Notably, ACP greatly lowered the obesity-related TNF-α- and IL-6-levels partially by reducing Desulfovibrio and increasing Parabacteroides abundances, together with the associated decrease of solavetivone level. These findings suggest that ACP may be used as a prebiotic agent to prevent diet-induced obesity, and target-specific microbiota and metabolites may have unique therapeutic promise for inflammation-related diseases.
3. Prebiotic Agrocybe cylindracea crude polysaccharides combined with Lactobacillus rhamnosus GG postpone aging-related oxidative stress in mice
Linxiu Wu, Xiaoyan Liu, Rongkang Hu, Yixuan Chen, Meifang Xiao, Bin Liu, Feng Zeng Food Funct. 2022 Feb 7;13(3):1218-1231. doi: 10.1039/d1fo02079j.
This study aimed to investigate the potential anti-aging mechanisms of Agrocybe cylindracea crude polysaccharides (APS), when used synergistically with Lactobacillus rhamnosus GG (APS + LGG) in a D-galactose-induced aging mouse model. In the Morris water maze test, APS + LGG showed a significantly higher memory and learning capacity compared to untreated, APS only treated and LGG treated mice. This was thought to be mediated by increased levels of brain-derived neurotrophic factor, which decreased escape latency. In addition to this, in the aging mouse model, APS + LGG co-treatment markedly alleviated liver oxidation and metabolism by enhancing the antioxidant activity of enzymes; this decreased the lipid metabolism and peroxidation levels. Furthermore, high throughput sequencing analysis revealed that an APS + LGG supplemented feed increased the relative abundance of positive bacteria in the gut microbiota such as Alloprevotella and Parvibacter. Importantly, Alloprevotella and Parvibacter showed a negative relationship with low density lipoprotein-cholesterol in the Spearman correlation analysis. These results illustrate that APS, in combination with LGG, postponed aging related oxidative stress when used as a prebiotic. The proposed mechanism for this is the reduction in liver oxidation and lipid metabolism, as well as the regulation of gut microbiota.

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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