AH-1763 IIa
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| Category | Antibiotics |
| Catalog number | BBF-03195 |
| CAS | |
| Molecular Weight | 378.37 |
| Molecular Formula | C22H18O6 |
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Description
AH-1763 la is an antibiotic produced by Streptomyces cyaneus against herpes virus. Its ED50 against herpes simplex virus type 1 (HSV-1) is 2.1 μg/mL, and its IC50 against Vero cells is 15.2 μg/mL.
Specification
| IUPAC Name | 11-Hydroxy-2-(3-hydroxybutan-2-yl)-5-methylnaphtho[2,3-h]chromene-4,7,12-trione |
| Canonical SMILES | CC1=CC2=C(C3=C1C(=O)C=C(O3)C(C)C(C)O)C(=O)C4=C(C2=O)C=CC=C4O |
| InChI | InChI=1S/C22H18O6/c1-9-7-13-19(21(27)18-12(20(13)26)5-4-6-14(18)24)22-17(9)15(25)8-16(28-22)10(2)11(3)23/h4-8,10-11,23-24H,1-3H3 |
| InChI Key | ONHCPBOKJBCMAX-UHFFFAOYSA-N |
Properties
| Appearance | Yellow Needle Crystal |
| Antibiotic Activity Spectrum | viruses |
| Boiling Point | 646.7±55.0°C at 760 mmHg |
| Melting Point | 224-226°C |
| Density | 1.4±0.1 g/cm3 |
Reference Reading
1. A new antiherpetic agent, AH-1763 IIa, produced by Streptomyces cyaneus strain no. 1763
M Uyeda, K Yokomizo, A Ito, K Nakayama, H Watanabe, Y Kido J Antibiot (Tokyo). 1997 Oct;50(10):828-32. doi: 10.7164/antibiotics.50.828.
A new antiherpetic agent, AH-1763 IIa, was isolated from the culture broth of strain No. 1763 identified as Streptomyces cyaneus. It was purified through column chromatographies of Diaion HP-10 and silica gel. The structure was determined to be 11-hydroxy-5-methyl-2-(2-hydroxy-1-methylpropyl)-4H-anthraceno [1,2-b]pyran-4,7,12-trione by several spectroscopic experiments, that is a new antibiotic belonging to pluramycin-group.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
