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AL-072

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Category Antibiotics
Catalog number BBF-03204
CAS 168482-44-8
Molecular Weight 649.04
Molecular Formula C41H76O5

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

AL072 is an antibiotic against Legionella produced by Strepyomyces sp. AL91. It has strong anti-legionella pneumophila activity.

  • Specification
  • Properties
  • Reference Reading
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IUPAC Name [2-hydroxy-3-[(9E,12E)-octadeca-9,12-dienoyl]oxypropyl] 14,16-dimethyloctadecanoate
Canonical SMILES CCCCCC=CCC=CCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCCCC(C)CC(C)CC)O
InChI InChI=1S/C41H76O5/c1-5-7-8-9-10-11-12-13-14-15-16-20-23-26-29-32-40(43)45-35-39(42)36-46-41(44)33-30-27-24-21-18-17-19-22-25-28-31-38(4)34-37(3)6-2/h10-11,13-14,37-39,42H,5-9,12,15-36H2,1-4H3/b11-10+,14-13+
InChI Key WFTOOGFFSZCCNW-IWCZYTNJSA-N
Appearance Colorless Oil
Antibiotic Activity Spectrum Gram-negative bacteria
Boiling Point 691.5±35.0°C at 760 mmHg
Density 0.9±0.1 g/ml
1. AL072, a novel anti-Legionella antibiotic produced by Streptomyces sp
C Yon, J W Suh, J H Chang, Y Lim, C H Lee, Y S Lee, Y W Lee J Antibiot (Tokyo). 1995 Aug;48(8):773-9. doi: 10.7164/antibiotics.48.773.
AL072 is a potent anti-Legionella antibiotic produced by Streptomyces strain AL91. The compound was isolated from the fermentation broth with 1 volume of isopropyl alcohol, followed by an ethyl acetate extraction and subsequent concentration under reduced pressure. Purification was performed on an octadecyl silica gel column followed by preparative HPLC. AL072 purified as mentioned above showed extremely specific activity only towards Legionella pneumophila. No antibacterial activity against any other bacteria tested was demonstrable. Its molecular weight was determined by FAB-MS (m/z 648) and the compound was identified as a novel 1,3-diacyl glycerol with the molecular formula C41H76O5. One of the two acyl groups is linoleyl and the other is 3,5-dimethyl octadecanoyl.

Bio Calculators

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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