Aladapcin
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Others |
| Catalog number | BBF-00398 |
| CAS | 114540-27-1 |
| Molecular Weight | 331.37 |
| Molecular Formula | C13H25N5O5 |
| Purity | 95% |
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Description
It is produced by the strain of Nocardia sp. SANK 60484. Alanine in 1-100 ㎍/kg can enhance the resistance of mice against experimental E. coli infection.
Specification
| Synonyms | SCHEMBL4061749; DTXSID90921412; N-{2-[(2,6-Diamino-1,7-dihydroxy-7-iminoheptylidene)amino]-1-hydroxypropylidene}alanine |
| IUPAC Name | 2-[2-[(2,6,7-triamino-7-oxoheptanoyl)amino]propanoylamino]propanoic acid |
| Canonical SMILES | CC(C(=O)NC(C)C(=O)O)NC(=O)C(CCCC(C(=O)N)N)N |
| InChI | InChI=1S/C13H25N5O5/c1-6(11(20)18-7(2)13(22)23)17-12(21)9(15)5-3-4-8(14)10(16)19/h6-9H,3-5,14-15H2,1-2H3,(H2,16,19)(H,17,21)(H,18,20)(H,22,23) |
| InChI Key | JPUODCQOVNYKMH-UHFFFAOYSA-N |
Properties
| Appearance | White Powder |
| Boiling Point | 772.6 °C at 760 mmHg |
| Density | 1.278 g/cm3 |
| Solubility | Soluble in Methanol, Water; Insoluble in Chloroform, Acetone |
Reference Reading
1. Aladapcin, a new microbial metabolite that enhances host resistance against bacterial infection. Production, isolation, physico-chemical properties and biological activities
A Shiraishi, M Nakajima, T Katayama, T Matsuda, T Niwa, T Okazaki, Y Takamatsu, H Nagaki, T Kinoshita, T Takatsu, et al. J Antibiot (Tokyo). 1990 Jun;43(6):634-8. doi: 10.7164/antibiotics.43.634.
We have constructed a new screening system for detecting microbial products that enhance host resistance against bacterial infection. It was found that a new compound with such activity is produced by a soil isolate classified as Nocardia sp. SANK 60484. The compound was isolated from the culture filtrate of the organism and named aladapcin after its amino acid composition. Aladapcin was obtained as an amphoteric white amorphous powder with the molecular formula, C13H25N5O5. It consists of 2 mol of D-alanine and 1 mol of meso-diaminopimelic acid. From the analysis of IR, 1H NMR and FAB-MS spectra, the structure was assigned to be a tripeptide. Aladapcin enhanced host resistance against an experimental Escherichia coli infection in mice at doses ranging between 1 and 100 micrograms/kg.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
