Amdinocillin pivoxil
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| Category | Antibiotics |
| Catalog number | BBF-00668 |
| CAS | 32886-97-8 |
| Molecular Weight | 439.57 |
| Molecular Formula | C21H33N3O5S |
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Description
Antibiotics, oral.
Specification
| Related CAS | 32887-03-9 (hydrochloride) |
| Synonyms | Pivmecillinam |
| Shelf Life | 2 years |
| Storage | Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -95℃ for long term (months to years). |
| IUPAC Name | 2,2-dimethylpropanoyloxymethyl (2S,5R,6R)-6-(azepan-1-ylmethylideneamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Canonical SMILES | CC1(C(N2C(S1)C(C2=O)N=CN3CCCCCC3)C(=O)OCOC(=O)C(C)(C)C)C |
| InChI | 1S/C21H33N3O5S/c1-20(2,3)19(27)29-13-28-18(26)15-21(4,5)30-17-14(16(25)24(15)17)22-12-23-10-8-6-7-9-11-23/h12,14-15,17H,6-11,13H2,1-5H3/t14-,15+,17-/m1/s1 |
| InChI Key | NPGNOVNWUSPMDP-HLLBOEOZSA-N |
Properties
| Appearance | Solid powder |
| Application | Anti-Bacterial Agents |
| Antibiotic Activity Spectrum | Gram-negative bacteria |
| Boiling Point | 581.0±60.0 °C | Condition: Press: 760 Torr |
| Melting Point | 118.5-119.5 °C |
| Density | 1.30±0.1 g/cm3 |
| Solubility | Soluble in Ethanol |
Reference Reading
1.Antibiotic prophylaxis for transrectal prostate biopsy-a new strategy.
Antsupova V1, Nørgaard N2, Bisbjerg R2, Nygaard Jensen J3, Boel J4, Jarløv JO3, Arpi M3. J Antimicrob Chemother. 2014 Dec;69(12):3372-8. doi: 10.1093/jac/dku293. Epub 2014 Aug 11.
BACKGROUND: Fluoroquinolones are extensively used as prophylaxis for transrectal ultrasound-guided biopsy of the prostate (TRUBP). Emerging fluoroquinolone resistance and selection of multiresistant organisms warrant new prophylactic strategies. Pivmecillinam and amoxicillin/clavulanic acid have mutual synergistic activity and the combination of these agents has a broad coverage of the majority of microorganisms causing infectious complications after TRUBP and may be a valuable future prophylactic regimen.
2.Mecillinam resistance and outcome of pivmecillinam treatment in uncomplicated lower urinary tract infection in women.
Monsen TJ, Holm SE, Ferry BM, Ferry SA. APMIS. 2014 Apr;122(4):317-23. doi: 10.1111/apm.12147.
Pivmecillinam (PIV) is a first-line antimicrobial for treatment of lower urinary tract infection in women (LUTIW). Mecillinam, the active substance of PIV, is bactericidal mainly against gram-negative uropathogens, whereas gram-positive species are considered intrinsically resistant. However, successful treatment of LUTIW caused by Staphylococcus saprophyticus has been reported, but more rarely for other gram-positive species. The aim of this study was to compare clinical and bacteriological outcome of PIV vs placebo treatment among uropathogens with special focus on mecillinam-resistant isolates. We analysed data from a prospective, multicentre, placebo-controlled, primary health care, therapy study performed in Sweden in 1995–1998 that included 1143 women with symptoms suggestive of LUTIW. Urine cultures were collected and symptoms registered at inclusion and at follow-up visits. Overall, the efficacy of PIV was superior to that of placebo.
3.[New aspects on diagnostics and therapy of uncomplicated cystitis].
Naber KG1. Urologe A. 2014 Oct;53(10):1489-94. doi: 10.1007/s00120-014-3564-7.
BACKGROUND: Acute uncomplicated cystitis in women is one of the most frequently diagnosed bacterial infections. A clinically symptomatic urinary tract infection must be differentiated from asymptomatic bacteriuria, which is not considered an infection but more a colonization which as a rule should not be treated. Acute cystitis can also be caused by a low number of uropathogenic bacteria, especially Escherichia coli, which is often overlooked during routine bacteriological diagnostics.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
