Amifostine thiol
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Bioactive by-products |
| Catalog number | BBF-04658 |
| CAS | 31098-42-7 |
| Molecular Weight | 134.25 |
| Molecular Formula | C5H14N2S |
| Purity | 95% |
Ordering Information
| Catalog Number | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| BBF-04658 | 100 mg | $239 | In stock |
Online Inquiry
Add to cartDescription
Amifostine Thiol is a metabolite of Amifostine. Amifostine thiol activates p53 through a JNK-dependent signaling pathway.
Specification
| Related CAS | 14653-77-1 (dihydrochloride) |
| Synonyms | 2-[(3-Aminopropyl)amino]-ethanethiol; N-(2-Mercaptoethyl)-1,3-diaminopropane; NSC 647527; WR 1065 |
| Storage | 0-6ºC |
| IUPAC Name | 2-(3-aminopropylamino)ethanethiol |
| Canonical SMILES | C(CN)CNCCS |
| InChI | InChI=1S/C5H14N2S/c6-2-1-3-7-4-5-8/h7-8H,1-6H2 |
| InChI Key | YHPLKWQJMAYFCN-UHFFFAOYSA-N |
Properties
| Appearance | White Solid |
| Boiling Point | 218.6±15.0 °C at 760 mmHg |
| Melting Point | 84ºC to 99.5ºC |
| Density | 0.975±0.06 g/cm3 |
| Solubility | Soluble in DMSO |
Reference Reading
1.Leaf Fertilizers Affect Survival and Behavior of the Neotropical Stingless Bee Friesella schrottkyi (Meliponini: Apidae: Hymenoptera).
Rodrigues CG1, Krüger AP2, Barbosa WF1, Guedes RN3. J Econ Entomol. 2016 Apr 11. pii: tow044. [Epub ahead of print]
The ongoing concern about bee decline has largely focused on honey bees and neonicotinoid insecticides, while native pollinators such as Neotropical stingless bees and agrochemicals such as other insecticide groups, pesticides in general, and fertilizers-especially leaf fertilizers-remain neglected as potential contributors to pollination decline. In an effort to explore this knowledge gap, we assessed the lethal and sublethal behavioral impact of heavy metal-containing leaf fertilizers in a native pollinator of ecological importance in the Neotropics: the stingless beeFriesella schrottkyi(Friese). Two leaf fertilizers-copper sulfate (24% Cu) and a micronutrient mix (Arrank L: 5% S, 5% Zn, 3% Mn, 0.6% Cu, 0.5% B, and 0.06% Mo)-were used in oral and contact exposure bioassays. The biopesticide spinosad and water were used as positive and negative controls, respectively. Copper sulfate compromised the survival of stingless bee workers, particularly with oral exposure, although less than spinosad under contact exposure.
2.Efficacy and safety of a novel oral isoxazoline, sarolaner (Simparica™) in the treatment of naturally occurring flea and tick infestations in dogs presented as veterinary patients in Europe.
Becskei C1, De Bock F2, Illambas J2, Mahabir SP3, Farkas R4, Six RH3. Vet Parasitol. 2016 Mar 16. pii: S0304-4017(16)30032-2. doi: 10.1016/j.vetpar.2016.02.007. [Epub ahead of print]
Two randomised, blinded, multi-centered field studies were conducted in Europe to demonstrate the efficacy and safety of three monthly oral doses of sarolaner (Simparica™, Zoetis) administered at a minimum dosage of 2.0mg/kg (range 2-4mg/kg) against natural flea or tick infestation of dogs presented as veterinary patients. In the flea study, the improvement in clinical signs associated with flea allergy dermatitis (FAD) was also investigated. The palatability of the sarolaner chewable tablet formulation was evaluated in both studies. Spinosad (Comfortis® Chewable Tablets, Elanco) and fipronil (Frontline® Spot on, Merial) were used as positive controls in the flea and tick study, respectively. Treatments were administered on Days 0, 30 and 60. Efficacy was calculated based on the mean percent reduction of live parasite counts on post-treatment days 14, 30, 60 and 90 versus the pre-treatment count on Day 0. Non-inferiority of sarolaner to the control products was assessed at each time-point using a margin of 15% at the one-sided 0.
3.Transcriptome Analysis of an Insecticide Resistant Housefly Strain: Insights about SNPs and Regulatory Elements in Cytochrome P450 Genes.
Mahmood K1, Højland DH1, Asp T2, Kristensen M1. PLoS One. 2016 Mar 28;11(3):e0151434. doi: 10.1371/journal.pone.0151434. eCollection 2016.
BACKGROUND: Insecticide resistance in the housefly, Musca domestica, has been investigated for more than 60 years. It will enter a new era after the recent publication of the housefly genome and the development of multiple next generation sequencing technologies. The genetic background of the xenobiotic response can now be investigated in greater detail. Here, we investigate the 454-pyrosequencing transcriptome of the spinosad-resistant 791spin strain in relation to the housefly genome with focus on P450 genes.
4.Toxicity and Nonrepellency of Spinosad and Spinetoram on Formosan Subterranean Termites (Isoptera: Rhinotermitidae).
Bhatta D1, Henderson G1, Gautam BK2. J Econ Entomol. 2016 Apr 22. pii: tow079. [Epub ahead of print]
Spinosyn products, spinosad and spinetoram, are widely used to control various agricultural pests. Spinosad has been tested on Kalotermitidae and Termitidae but not on Rhinotermitidae, the most destructive of termite families. In this study, we tested the effect of spinosad and spinetoram on Coptotermes formosanus Shiraki. Both no-choice and choice tests were conducted using three concentrations, 1 ppm, 25 ppm, and 50 ppm, of the spinosyn products Entrust, Tracer, and Radiant on three substrates, sand, soil, and filter paper. In the no-choice test in sand, >85% mortality was observed at 25 and 50 ppm after 1 d of exposure followed by 100% mortality at 7 d. Similarly, after 7 d at 25 and 50 ppm in soil and filter paper, 100% mortality was observed, but compared to sand at 1 d, mortality was low. In the two-choice test, observations before the onset of termite mortality showed that none of the products or concentrations was repellent. Likewise, in the multiple-choice test, there was no repellency or preference of termites among 1 ppm, 25 ppm, 50 ppm, control, and release chamber at all three concentrations, and the tunnel area in the control and treated choices were not significantly different.
Recommended Products
| BBF-01829 | Deoxynojirimycin | Inquiry |
| BBF-03755 | Actinomycin D | Inquiry |
| BBF-02614 | Nystatin | Inquiry |
| BBF-01826 | Deoxymannojirimycin | Inquiry |
| BBF-01825 | Loganin | Inquiry |
| BBF-00764 | Cerebroside C | Inquiry |
Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
