Amikacin
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| Category | Antibiotics |
| Catalog number | BBF-00673 |
| CAS | 37517-28-5 |
| Molecular Weight | 585.60 |
| Molecular Formula | C22H43N5O13 |
| Purity | 98% |
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Description
It has a wide antibacterial spectrum and is effective to most kanamycin resistant bacteria.
Specification
| Related CAS | 149022-22-0 (Sulfate) |
| Synonyms | (S)-O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-D-streptamine; 1-N-[L-(-)-γ-Amino-α-hydroxybutyryl]kanamycin A; Amicacin; Amikacillin; Amikacin; Amikozit; Amukin; Antibiotic BB-K 8; Arikace; BAY 41-6551; BAY 416651; BB-K 8; Lukadin; Potentox |
| Storage | Store at -20°C, under inert atmosphere |
| IUPAC Name | (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide |
| Canonical SMILES | C1C(C(C(C(C1NC(=O)C(CCN)O)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)O)N |
| InChI | InChI=1S/C22H43N5O13/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+/m0/s1 |
| InChI Key | LKCWBDHBTVXHDL-RMDFUYIESA-N |
| Source | Semi-synthetic |
Properties
| Appearance | White Powder |
| Application | Anti-bacterial agents |
| Boiling Point | 981.8 °C at 760 mmHg |
| Melting Point | 203-204 °C |
| Density | 1.600 g/cm3 |
| Solubility | Soluble in Water |
Reference Reading
1.Colistin-sparing regimens against Klebsiella pneumoniae carbapenemase-producing K. pneumoniae isolates: Combination of tigecycline or doxycycline and gentamicin or amikacin.
Tang HJ1, Lai CC2, Chen CC3, Zhang CC4, Weng TC4, Chiu YH5, Toh HS4, Chiang SR4, Yu WL6, Ko WC7, Chuang YC8. J Microbiol Immunol Infect. 2016 Mar 31. pii: S1684-1182(16)30024-X. doi: 10.1016/j.jmii.2016.03.003. [Epub ahead of print]
BACKGROUND/PURPOSE: In vitro studies of the combination of an aminoglycoside with tigecycline or doxycycline against Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates are rarely published. The goal of this study was to evaluate the antibacterial activity of the combination regimens.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
