Anisomycin
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| Category | Antineoplastic |
| Catalog number | BBF-00692 |
| CAS | 22862-76-6 |
| Molecular Weight | 265.30 |
| Molecular Formula | C14H19NO4 |
| Purity | ≥98% |
Ordering Information
| Catalog Number | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| BBF-00692 | 500 mg | $239 | In stock | |
| BBF-00692 | 1 g | $470 | In stock |
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Add to cartDescription
It is produced by the strain of Streptomyces griseolus. It inhibits protein synthesis. it has anti-fungal, anti-fine bacteria, anti-tumor and antigenic insect action.
Specification
| Synonyms | Flagecidin; NSC-76712; AI3-50846; NSC76712; AI350846; NSC 76712; AI3 50846 |
| Shelf Life | 2 years if stored properly |
| Storage | 3 years -20°Cpowder;6 months-80°Cin solvent |
| IUPAC Name | [(2R,3S,4S)-4-hydroxy-2-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl] acetate |
| Canonical SMILES | O[C@@H]1[C@H]([C@@H](CC(C=C2)=CC=C2OC)NC1)OC(C)=O |
| InChI | InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1 |
| InChI Key | YKJYKKNCCRKFSL-RDBSUJKOSA-N |
Properties
| Appearance | White powder |
| Antibiotic Activity Spectrum | neoplastics (Tumor); fungi; parasites |
| Boiling Point | 398.7 °C at 760 mmHg |
| Melting Point | 140-141 °C |
| Density | 1.210 g/cm3 |
| Solubility | Soluble in Methanol, Ethanol |
Reference Reading
1.microRNA let-7c is essential for the anisomycin-elicited apoptosis in Jurkat T cells by linking JNK1/2 to AP-1/STAT1/STAT3 signaling.
Zhou Z1,2, Lu X1, Wang J1, Xiao J1, Liu J3, Xing F1,2. Sci Rep. 2016 Apr 18;6:24434. doi: 10.1038/srep24434.
Anisomycin, an antibiotic produced by Streptomyces griseolus, strongly induces apoptosis in various tumor cells in vitro, superior dramatically to adriamycin. The present study aims to elucidate its detailed mechanistic process. The results showed that anisomycin sufficiently promoted the apoptosis in human leukemic Jurkat T cells at a quite low dose. microRNA let-7c (let-7c) contributed to the anisomycin-induced apoptosis, which could be abrogated by the inactivation of JNK signaling. The let-7c over-expression and the addition of its mimics facilitated the activation of AP-1, STAT1 and Bim by linking JNK1/2 to AP-1/STAT1, but rather inhibited the activation of STAT3 and Bcl-xL by connecting JNK1/2 to STAT3, followed by the augmented apoptosis in the cells. The let-7c deficiency reduced the AP-1, STAT1 and Bim activities, and enhanced the STAT3 and Bcl-xL, alleviating the anisomycin-induced apoptosis. The knockdown of the bim gene repressed the anisomycin-boosted apoptosis through the attenuation of the active Bak and Bax.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
