Anthranilamide 2b

Anthranilamide 2b

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Category Others
Catalog number BBF-00483
CAS
Molecular Weight 295.33
Molecular Formula C18H17NO3

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Description

It is produced by the strain of Streptomyces sp. B7747. Antichlorella activity. MIC is 20-107μg/mL. Anthranilamide 2b is more active than the corresponding free acid. All the anthranilamide has no antibacterial activity against Staphylococcus aureus, Escherichia coli and Mucor mirabilis.

Specification

IUPAC Name methyl 2-(N-methylcinnamamido)benzoate

Reference Reading

1. Anthranilamides: new antimicroalgal active substances from a marine Streptomyces sp
M A Biabani, M Baake, B Lovisetto, H Laatsch, E Helmke, H Weyland J Antibiot (Tokyo). 1998 Mar;51(3):333-40. doi: 10.7164/antibiotics.51.333.
2-[Methyl-(3-phenylpropionyl)amino]-benzoic acid (1e) was isolated from a culture of marine Streptomyces sp. strain B7747. Analogous compounds have potential importance as phytotoxic substances, hence compound 1e and the analogues 1a approximately 1d and 1f approximately 3a were synthesised. Antimicroalgal activity of the anthranilamide analogues showed that esters 1b, 1f and 2b were more active than the free acids. The minimum inhibitory concentration (MIC) against Chlorella vulgaris, Chlorella sorokiniana, Chlorella salina and Scenedesmus subspicatus ranged from 20 to 107 micrograms/ml. All anthranilamides were inactive against Staphylococcus aureus, Escherichia coli, and Mucor miehei.

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