Antibiotic 1233B
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| Category | Enzyme inhibitors |
| Catalog number | BBF-03009 |
| CAS | 34668-58-1 |
| Molecular Weight | 342.43 |
| Molecular Formula | C18H30O6 |
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Description
It is a β-lactone antibiotic produced by the strain of Cephalosporium sp. It has a strong inhibitory effect on hydroxymethyl glutaryl coenzyme A (HMG-CoA) synthase.
Specification
| Synonyms | 1233B; 3,5,7-trimethyl-12-hydroxy-13-hydroxymethyl-2,4-tetradecadiendioic acid; 2,4-Tetradecadienedioic acid, 12-hydroxy-13-(hydroxymethyl)-3,5,7-trimethyl- |
| IUPAC Name | 12-hydroxy-13-(hydroxymethyl)-3,5,7-trimethyltetradeca-2,4-dienedioic acid |
| Canonical SMILES | CC(CCCCC(C(CO)C(=O)O)O)CC(=CC(=CC(=O)O)C)C |
| InChI | InChI=1S/C18H30O6/c1-12(8-13(2)9-14(3)10-17(21)22)6-4-5-7-16(20)15(11-19)18(23)24/h9-10,12,15-16,19-20H,4-8,11H2,1-3H3,(H,21,22)(H,23,24) |
| InChI Key | QFZISQBFEIXWDM-UHFFFAOYSA-N |
Properties
| Appearance | Crystal |
| Boiling Point | 547.5±50.0°C at 760 mmHg |
| Melting Point | 88-94°C |
| Density | 1.1±0.1 g/cm3 |
| Solubility | Soluble in Ether |
Reference Reading
1. Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene
Sho Kato, Takayuki Motoyama, Masakazu Uramoto, Toshihiko Nogawa, Takashi Kamakura, Hiroyuki Osada J Antibiot (Tokyo). 2020 Jul;73(7):475-479. doi: 10.1038/s41429-020-0295-4. Epub 2020 Mar 5.
We found that the protein synthesis inhibitor hygromycin B induced the production of secondary metabolites, including lucilactaene, NG-391, fusarubin, 1233A, and 1233B, in the filamentous fungus, Fusarium sp. RK97-94. We identified the biosynthetic gene cluster for 1233A, an HMG-CoA synthase inhibitor. The biosynthetic gene cluster consisted of four genes, one of which was involved in conferring self-resistance to 1233A.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
