Antibiotic 44161
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-03018 |
| CAS | 66771-51-5 |
| Molecular Weight | 746.96 |
| Molecular Formula | C42H66O11 |
Online Inquiry
Description
Antibiotic 44161 is a polyether antibiotic produced by the strain of Dactylosporangium salmoneum F. D. 26647. It has anti-gram-positive bacteria and coccidiococci activity, and can promote the growth of animals.
Properties
| Appearance | Crystal |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Parasites |
| Melting Point | 155-157°C (dec.) |
| Solubility | Soluble in Methanol, Acetone; Insoluble in Water |
Reference Reading
1. Discovery of anti-varicella zoster virus activity of polyether antibiotic CP-44161
Yukiko Yamagishi, Chihoko Ueno, Akemi Kato, Hirohito Kai, Hiromi Sasamura, Motoi Ueno, Bunji Sato, Akihiko Fujie, Takashi Fujii, Motohiro Hino, Eisaku Tsujii J Antibiot (Tokyo). 2009 Feb;62(2):89-93. doi: 10.1038/ja.2008.19. Epub 2009 Jan 23.
In search for new anti-varicella zoster virus (VZV) compounds with new mechanism of action, we applied a DNA hybridization assay (dot blot method) for screening. Using this method, we screened microbial products and found the polyether compound CP-44161 from the culture broth of an actinomycete strain. CP-44161 was previously reported as an anticoccidal agent, but there has been no claim of its antiviral activities. CP-44161 showed strong anti-VZV activity against pOka strain by plaque reduction assay. Moreover, CP-44161 showed lower cytotoxicity than other antiviral polyethers, such as monensin and nigericin. Its better safety margin and strong anti-VZV properties make it a good candidate for a new anti-VZV agent.
2. Anti-herpes virus activity of polyether antibiotic CP-44161 in vivo
Yukiko Yamagishi, Motoi Ueno, Chihoko Ueno, Akemi Kato, Ryuichi Kanasaki, Bunji Sato, Koji Takakura, Akihiko Fujie, Hidenori Nakajima, Takashi Fujii, Motohiro Hino, Eisaku Tsujii J Antibiot (Tokyo). 2009 Feb;62(2):95-8. doi: 10.1038/ja.2008.18. Epub 2009 Jan 23.
In the previous study, we discovered a polyether antibiotic CP-44161, which was reported earlier as an anticoccidal agent, as an anti-varicella zoster virus compound. In this study, we demonstrated that CP-44161 had a very strong and broad anti-herpes virus activities against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro. To determine the antiviral activity of CP-44161 in vivo, we examined its effect on the cutaneous HSV-2 infection model in Balb/c mice. CP-44161 showed inhibitory effect on lesion development as well as acyclovir (ACV) when the treatment was started from day 3. Meanwhile, in case the start of treatment was delayed until day 4, when ACV was no longer effective, the effectiveness of CP-44161 still remained. In this model, CP-44161 also showed inhibitory effect on the proliferation of HSV-2 DNA in dorsal root ganglia. This is the first article to report that polyether antibiotics can be effective on viral infection in vivo.
Recommended Products
| BBF-01825 | Loganin | Inquiry |
| BBF-01829 | Deoxynojirimycin | Inquiry |
| BBF-01693 | Doxorubicin EP Impurity A (Daunorubicin) | Inquiry |
| BBF-03754 | CASTANOSPERMINE | Inquiry |
| BBF-00764 | Cerebroside C | Inquiry |
| BBF-02614 | Nystatin | Inquiry |
Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
