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Antibiotic 6016

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Antibiotic 6016
Category Antibiotics
Catalog number BBF-03014
CAS 69421-39-2
Molecular Weight 887.10
Molecular Formula C46H78O16

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

It is a polyether antibiotic produced by the strain of Streptomyces sp. 6016. It has ionic carrier properties and has anti-gram-positive bacteria and weak anti-fungal and anti-coccidiococcal activity.

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Related CAS 69460-98-6 (sodium salt)
Synonyms Antibiotic K 41, 6,15-didemethoxy-27-de((tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl)oxy)-18-((tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl)oxy)-; Antibiotic NO 6016; BRN 1615219
IUPAC Name (2R)-2-hydroxy-2-[(2R,3S,4R,5R,6S)-2-hydroxy-6-[[(2S,4R,5R,6R,7R,9S)-2-[(2R,3R,5S)-5-[(2R,5R)-5-[(2S,3S,5R,6S)-6-hydroxy-3,5,6-trimethyloxan-2-yl]oxolan-2-yl]-3-[(5S,6R)-5-methoxy-6-methyloxan-2-yl]oxyoxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-4-methoxy-3,5-dimethyloxan-2-yl]acetic acid
Canonical SMILES CC1CC(C(OC1C2CCC(O2)C3CC(C(O3)C4(CC(C5(O4)C(C(CC(O5)CC6C(C(C(C(O6)(C(C(=O)O)O)O)C)OC)C)OC)C)C)C)OC7CCC(C(O7)C)OC)(C)O)C
InChI InChI=1S/C46H78O16/c1-22-17-23(2)44(9,50)61-38(22)32-14-13-31(56-32)35-20-36(57-37-16-15-30(52-10)28(7)55-37)41(58-35)43(8)21-24(3)46(62-43)26(5)34(53-11)19-29(59-46)18-33-25(4)39(54-12)27(6)45(51,60-33)40(47)42(48)49/h22-41,47,50-51H,13-21H2,1-12H3,(H,48,49)/t22-,23+,24+,25+,26+,27-,28+,29+,30-,31+,32+,33-,34+,35-,36+,37?,38-,39+,40-,41+,43-,44-,45+,46+/m0/s1
InChI Key AINDPXHXPBFFDG-GTCKFIOPSA-N
Antibiotic Activity Spectrum Gram-positive bacteria; Fungi; Parasites
Boiling Point 891.1±65.0°C at 760 mmHg
Density 1.3±0.1 g/cm3
Solubility Soluble in Methanol
1. Antibiotic no. 6016, a polyether antibiotic
Y Kusakabe, S Mitsuoka, Y Omuro, A Seino J Antibiot (Tokyo). 1980 Dec;33(12):1437-42. doi: 10.7164/antibiotics.33.1437.
A new polyether antibiotic, No. 6016, was isolated from the culture of Streptomyces albus strain No. 6016. The antibiotic was obtained as colorless prisms having a molecular formula of C46H77O16Na, m.p. 192 approximately 195 degrees C (dec.), and has only end absorption in ultraviolet region. The infrared and NMR spectra of the antibiotic suggest the presence of carbonyl and methoxyl groups. The antibiotic No. 6016 exhibits activity against Gram-positive bacteria including mycobacteria and is effective in the treatment of coccidiosis of fowl.

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