Metabolites-BOC Sciences

Antibiotic A-447D

Antibiotic A-447D - CAS 107480-96-6

Catalog number: BBF-03039

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Catalog Number BBF-03039
CAS 107480-96-6
Description It is an anthracycline antibiotic produced by the strain of Streptomyces cyaneus (A-447). It can inhibit the growth of P388 murine lymphocytic leukemia cells with IC50 of 1.4 ng/mL.
Molecular Formula C60H86N2O21
Molecular Weight 1171.32
Antibiotic Activity Spectrum Neoplastics (Tumor)
Synonyms A447 D; (3''S)-4''''''-Deoxy-3''-hydroxy-4''''''-oxocytorhodin A; Cytorhodin A, 4F-deoxy-3B-hydroxy-4F-oxo-, (3BS)-; 5,12-Naphthacenedione, 8-ethyl-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-10-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2S,5S,6S)-tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]-a-L-lyxo-hexopyranosyl]-3-(dimethylamino)-a-L-lyxo-hexopyranosyl]oxy]-7-[[2,3,6-trideoxy-3-(dimethylamino)-4-O-[(2S,5S,6S)-tetrahydro-6-methyl-5-[[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]oxy]-2H-pyran-2-yl]-a-L-lyxo-hexopyranosyl]oxy]-, (7R,8R,10S)-
IUPAC Name (7R,8R,10S)-10-(((2R,4S,5S,6S)-4-(dimethylamino)-5-(((2S,4S,5S,6S)-4-hydroxy-5-(((2S,5S,6S)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-7-(((2S,4S,5S,6S)-4-(dimethylamino)-6-methyl-5-(((2S,5S,6S)-6-methyl-5-(((2R,6S)-6-methyl-5-oxotetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-8-ethyl-1,6,8,11-tetrahydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione
Melting Point 175-180°C (dec.)
Solubility Soluble in Methanol
Appearance Red Powder
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