Antibiotic A 9145C
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| Category | Antibiotics |
| Catalog number | BBF-03050 |
| CAS | 66753-47-7 |
| Molecular Weight | 379.37 |
| Molecular Formula | C15H21N7O5 |
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Description
It is a nucleoside antibiotic produced by the strain of Streptomyces griseolus (NRRL 3739). It has the effect against plant pathogenic fungi, candida, Pasteur's yeast and trypanosome.
Specification
| Synonyms | Dehydrosinefungin; Antibiotic SF 1306A; A 9145C; 6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-Dec-4-enofuranuronic acid |
| IUPAC Name | (2S,5S,6E)-2,5-diamino-6-[(3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-ylidene]hexanoic acid |
| Canonical SMILES | C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(=CC(CCC(C(=O)O)N)N)O3)O)O)N |
| InChI | InChI=1S/C15H21N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h3-7,10-11,14,23-24H,1-2,16-17H2,(H,25,26)(H2,18,19,20)/b8-3+/t6-,7-,10+,11+,14+/m0/s1 |
| InChI Key | YNKCTZQHSHSLNN-XVIGKWCNSA-N |
Properties
| Antibiotic Activity Spectrum | Fungi; Parasites; Yeast |
| Boiling Point | 819.9°C at 760 mmHg |
| Density | 1.90 g/cm3 |
| Solubility | Soluble in Water; Slightly soluble in Methanol, Ethanol; Insoluble in other organic solvents |
Reference Reading
1. Antifungal antibiotics and Siba inhibit 1-aminocyclopropane-1-carboxylic acid synthase activity
I Icekson, A Apelbaum Biochem Biophys Res Commun. 1983 Jun 15;113(2):586-91. doi: 10.1016/0006-291x(83)91766-7.
The antifungal antibiotics Sinefungin and A9145C isolated from Streptomyces griseolus and the synthetic nucleoside Siba, which are analogs of S-adenosylmethionine, inhibit the activity of 1-aminocyclopropane 1-carboxylic acid synthase from tomato fruits. Sinefungin and Siba were shown to be more potent inhibitors than A9145C. In extracts of green fruits, the enzyme activity was inhibited by Sinefungin with an I50 of 1 microM, which was similar to that caused by aminoethoxyvinylglycine, and by Siba with an I50 of 100 microM; in extracts from red tomatoes, the I50's were 25 microM and 100 microM, respectively. The inhibition of ACC synthase by these analogs could be reversed by gel filtration chromatography.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
