Antibiotic PF 1052
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| Category | Antibiotics |
| Catalog number | BBF-04510 |
| CAS | 147317-15-5 |
| Molecular Weight | 429.59 |
| Molecular Formula | C26H39NO4 |
| Purity | ≥95% |
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Description
Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma sp. It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 µg/ml, respectively). Antibiotic PF 1052 inhibits neutrophil migration in a wound assay and reduces pseudopodia formation.
Specification
| Synonyms | (E)-5-(sec-Butyl)-3-((2-(2,3-dimethyloxiran-2-yl)-6,8-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)(hydroxy)methylene)-1-methylpyrrolidine-2,4-dione; PF 1052; 3-[[2-(2,3-Dimethyl-2-oxiranyl)-1,2,4a,5,6,7,8,8a-octahydro-6,8-dimethyl-1-naphthalenyl]hydroxymethylene]-1-methyl-5-(1-methylpropyl)-2,4-pyrrolidinedione |
| Storage | Store at -20°C |
| IUPAC Name | (3E)-5-butan-2-yl-3-[[2-(2,3-dimethyloxiran-2-yl)-6,8-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]-hydroxymethylidene]-1-methylpyrrolidine-2,4-dione |
| Canonical SMILES | CC1CC(C)C2C(C=CC(C3(C)C(C)O3)C2/C(O)=C4C(N(C)C(C(C)CC)C\4=O)=O)C1 |
| InChI | InChI=1S/C26H39NO4/c1-8-14(3)22-24(29)21(25(30)27(22)7)23(28)20-18(26(6)16(5)31-26)10-9-17-12-13(2)11-15(4)19(17)20/h9-10,13-20,22,28H,8,11-12H2,1-7H3/b23-21+ |
| InChI Key | NPWKEUKXVOMELT-XTQSDGFTSA-N |
Properties
| Appearance | Oily Matter |
| Antibiotic Activity Spectrum | Bacteria |
| Solubility | Soluble in Dichloromethane, Methanol, Chloroform |
Reference Reading
1. Discoloration of teeth after avulsion and replantation: results from a multicenter randomized controlled trial
Monty S Duggal, Angus Robertson, Stephen Westland, Terry A Gregg, Alec S High, Paul F Ashley, Richard R Welbury, Ben O Cole, Peter F Day J Endod . 2011 Aug;37(8):1052-7. doi: 10.1016/j.joen.2011.04.014.
Introduction:There is evidence to suggest that Ledermix, placed as an intervisit root canal dressing, might improve periodontal healing after replantation of avulsed teeth. As a part of a multicenter randomized controlled trial, we aimed to compare the effect of 2 root canal medicaments, Ledermix and Ultracal XS, on the discoloration of replanted teeth.Methods:Discoloration was investigated by using 3 methods: patient satisfaction with the color of replanted teeth, clinical photographs taken at baseline and 12-month reviews, and estimation of color change by using CIELAB scores for baseline and 12-month photographs.Results:Twenty-two patients (27 teeth) were recruited. Ten patients (12 teeth) were randomized to the Ledermix group and 12 patients (15 teeth) to the Ultracal XS group. At 12 months, 8 patients were concerned with the discoloration of their teeth. Seven came from the Ledermix group and 1 from the Ultracal XS group. This difference was significant (Fisher exact test, P = .009). Standardized photographs were taken for the patients recruited at one center only (17 patients). There was significant discoloration of teeth from baseline with Ledermix, causing a darkening and gray-brown discoloration (mean change from baseline to 12 months, L* = -5.1, a* = 0.3, b* = -1.2, and ΔE = 8.1) and Ultracal XS, causing a yellowing and lightening of teeth (L* = 1.9, a* = 0.3, b* = 3.3, and ΔE = 5.4). There was a significant difference for the L* and b* variables (independent t test) between the 2 groups.Conclusions:Both root canal medicaments cause discoloration, with Ledermix proving less acceptable to patients.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
