APHE-2
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-03291 |
| CAS | 93773-64-9 |
| Molecular Weight | 226.27 |
| Molecular Formula | C14H14N2O |
Online Inquiry
Description
APHE-2 is a pyrazoloisoquinolinone antibiotic produced by Streptoverticillium griseocarneum. It has weak anti-Gram-positive bacteria activity.
Specification
| Synonyms | 1H-Indole, 3-(2-propyl-5-oxazolyl)-; WS-30581A |
| IUPAC Name | 5-(1H-indol-3-yl)-2-propyl-1,3-oxazole |
| Canonical SMILES | CCCC1=NC=C(O1)C2=CNC3=CC=CC=C32 |
| InChI | InChI=1S/C14H14N2O/c1-2-5-14-16-9-13(17-14)11-8-15-12-7-4-3-6-10(11)12/h3-4,6-9,15H,2,5H2,1H3 |
| InChI Key | KCQVQYHMHWZCAL-UHFFFAOYSA-N |
Properties
| Antibiotic Activity Spectrum | Gram-positive bacteria |
| Boiling Point | 390.4±45.0°C at 760 mmHg |
| Density | 1.2±0.1 g/cm3 |
Reference Reading
1. APHE-3, a spore-associated antibiotic of Streptomyces griseocarneus NCIMB 40447
R Cruz, M E Arias, J Soliveri Appl Microbiol Biotechnol. 2000 Apr;53(4):480-3. doi: 10.1007/s002530051645.
Solid cultures of the producing strain grown on Bennett medium develop abundant mycelium and intense sporulation. Under these conditions biosynthesis of APHE antibiotics (APHE-1 to -3) is accomplished. Further studies show that APHE-3 is basically produced during spore formation and mostly present in spores, while APHE-1 and APHE-2 are the predominant antibiotics in the mycelium. APHE compounds are present in almost all streptomycetes tested, indicating a possible role in the life cycle of these microorganisms.
2. APHE-1 and APHE-2, two new antimicrobial and cytotoxic antibiotics. II. Physico-chemical properties and structure elucidation
M L Fidalgo, M S Arias, J Soliveri, M E Arias J Antibiot (Tokyo). 1992 Nov;45(11):1759-62. doi: 10.7164/antibiotics.45.1759.
Two new pyrazolo-isoquinolinone antibiotics, APHE-1 and APHE-2, have been isolated from the culture filtrate and mycelia of Streptoverticillium griseocarneum NCIMB 40447. Molecular formulae were established as C13H12N2O for APHE-1 and C14H14N2O for APHE-2, by elemental analysis, NMR and mass spectra. 2D NMR techniques (1H-1H COSY-45 and 1H-13C correlated spectroscopy) have been applied to establish their structures.
3. APHE-1 and APHE-2, two new antimicrobial and cytotoxic antibiotics. I. Taxonomy, fermentation, isolation and biological activity
M L Fidalgo, J L Alonso, J Soliveri, M E Arias J Antibiot (Tokyo). 1992 Nov;45(11):1753-8. doi: 10.7164/antibiotics.45.1753.
APHE-1 and APHE-2 are two new antibiotics produced by Streptoverticillium griseocarneum NCIMB 40447. They exhibited a remarkable cytotoxic activity against several tumor cell lines from different origin. Furthermore, they showed weak antimicrobial activity against Gram-positive bacteria, filamentous fungi and yeasts.
Recommended Products
| BBF-03755 | Actinomycin D | Inquiry |
| BBF-02642 | Lactonamycin | Inquiry |
| BBF-05862 | Epirubicin | Inquiry |
| BBF-03754 | CASTANOSPERMINE | Inquiry |
| BBF-02614 | Nystatin | Inquiry |
| BBF-01826 | Deoxymannojirimycin | Inquiry |
Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
