APHE-3
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| Category | Antibiotics |
| Catalog number | BBF-03524 |
| CAS | 13640-26-1 |
| Molecular Weight | 198.22 |
| Molecular Formula | C12H10N2O |
| Purity | >95% by HPLC |
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Description
APHE-3 is a pyrazoloisoquinolinone antibiotic produced by Streptoverticillium griseocarneum. It has weak anti-Gram-positive bacteria activity. APHE-3 can also inhibit lymphocyte proliferation in the presence of Phytohemagglutinin, with IC50 of about 0.1 mmol/L.
Specification
| Synonyms | Pimprinine; WS 30581C |
| Storage | -20°C |
| IUPAC Name | 5-(1H-indol-3-yl)-2-methyl-1,3-oxazole |
| Canonical SMILES | CC1=NC=C(O1)C2=CNC3=CC=CC=C32 |
| InChI | InChI=1S/C12H10N2O/c1-8-13-7-12(15-8)10-6-14-11-5-3-2-4-9(10)11/h2-7,14H,1H3 |
| InChI Key | WZJPGCHCOHYLMB-UHFFFAOYSA-N |
| Source | Streptomyces sp. |
Properties
| Appearance | Tan Powder |
| Antibiotic Activity Spectrum | Gram-positive bacteria |
| Boiling Point | 369.5±45.0°C at 760 mmHg |
| Density | 1.3±0.1 g/cm3 |
| Solubility | Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility. |
Reference Reading
1. APHE-3, a spore-associated antibiotic of Streptomyces griseocarneus NCIMB 40447
M E Arias, R Cruz, J Soliveri Appl Microbiol Biotechnol . 2000 Apr;53(4):480-3. doi: 10.1007/s002530051645.
Solid cultures of the producing strain grown on Bennett medium develop abundant mycelium and intense sporulation. Under these conditions biosynthesis of APHE antibiotics (APHE-1 to -3) is accomplished. Further studies show that APHE-3 is basically produced during spore formation and mostly present in spores, while APHE-1 and APHE-2 are the predominant antibiotics in the mycelium. APHE compounds are present in almost all streptomycetes tested, indicating a possible role in the life cycle of these microorganisms.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
