Aranorosin
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Category | Enzyme inhibitors |
Catalog number | BBF-03967 |
CAS | 117184-53-9 |
Molecular Weight | 419.51 |
Molecular Formula | C23H33NO6 |
Purity | ≥95% |
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Description
Aranorosin is a fungal metabolite originally isolated from P. roseus and an inhibitor of anti-apoptotic functions regulated by Bcl-2. It has antimicrobial activity against B. subtilis, A. niger, and C. albicans when used at a concentration of 1 mg/ml. Aranorosin also reduces viability in apoptosis-resistant HeLa/Bcl-2 cells. Aranorosin also inhibits enzyme AAC(6')/APH(2'') which plays a role in arbekacin (ABK)-resistance in MRSA.
Specification
Synonyms | Spiro[4,8-dioxatricyclo[5.1.0.03,5]octane-2,2'(3'H)-furan], 2,4-dodecadienamide deriv.; Aranorosine |
Storage | Store at -20°C |
IUPAC Name | (2E,4E,6R)-N-[(1S,3R,5S,7R)-2'-hydroxy-6-oxospiro[4,8-dioxatricyclo[5.1.0.03,5]octane-2,5'-oxolane]-3'-yl]-4,6-dimethyldodeca-2,4-dienamide |
Canonical SMILES | CCCCCCC(C)C=C(C)C=CC(=O)NC1CC2(C3C(O3)C(=O)C4C2O4)OC1O |
InChI | InChI=1S/C23H33NO6/c1-4-5-6-7-8-13(2)11-14(3)9-10-16(25)24-15-12-23(30-22(15)27)20-18(28-20)17(26)19-21(23)29-19/h9-11,13,15,18-22,27H,4-8,12H2,1-3H3,(H,24,25)/b10-9+,14-11+/t13-,15+,18-,19+,20-,21+,22-,23-/m1/s1 |
InChI Key | JHTWWPWUODMKEO-ZVNJHPNESA-N |
Properties
Appearance | Solid Powder |
Antibiotic Activity Spectrum | Gram-positive bacteria; fungi |
Boiling Point | 650.4°C at 760 mmHg |
Density | 1.23 g/cm3 |
Solubility | Soluble in DMSO, ethanol, methanol |
Reference Reading
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2