Arbekacin sulfate
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-04120 |
| CAS | 104931-87-5 |
| Molecular Weight | 650.70 |
| Molecular Formula | C22H46N6O14S |
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Description
Arbekacin is a semi-synthetic aminoglycoside antibiotic used to treat infections caused by methicillin-resistant Staphylococcus aureus (MRSA).
Specification
| Related CAS | 51025-85-5 (free base) |
| Synonyms | Habekacin |
| IUPAC Name | (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(2R,3R,6S)-3-amino-6-(aminomethyl)oxan-2-yl]oxy-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide;sulfuric acid |
| Canonical SMILES | C1CC(C(OC1CN)OC2C(CC(C(C2O)OC3C(C(C(C(O3)CO)O)N)O)NC(=O)C(CCN)O)N)N.OS(=O)(=O)O |
| InChI | InChI=1S/C22H44N6O10.H2O4S/c23-4-3-12(30)20(34)28-11-5-10(26)18(37-21-9(25)2-1-8(6-24)35-21)17(33)19(11)38-22-16(32)14(27)15(31)13(7-29)36-22;1-5(2,3)4/h8-19,21-22,29-33H,1-7,23-27H2,(H,28,34);(H2,1,2,3,4)/t8-,9+,10-,11+,12-,13+,14-,15+,16+,17-,18+,19-,21+,22+;/m0./s1 |
| InChI Key | UTUVRPOLEMRKQC-XDJMXTNXSA-N |
Properties
| Appearance | White Solid |
| Antibiotic Activity Spectrum | Gram-positive bacteria |
| Boiling Point | 904°C at 760 mmHg |
| Melting Point | >210°C (dec.) |
Reference Reading
1.Is there a role for Digital X-ray Radiogrammetry as surrogate marker for radiological progression and imaging of structural integrity in rheumatoid arthritis?
Pfeil A1, Oelzner P2, Renz DM3, Hansch A4, Wolf G5, Böttcher J6. BMC Musculoskelet Disord. 2015 Jun 23;16:155. doi: 10.1186/s12891-015-0577-3.
INTRODUCTION: The established scoring techniques based on radiographs present limitations in the evaluation of structural integrity due to high effectiveness of innovative therapeutic strategies. The aim of this study was to evaluate the periarticular mineralisation as detected by Digital X-ray Radiogrammetry (DXR) as surrogate marker for structural integrity during the course of rheumatoid arthritis (RA).
2.Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT₁A and 5-HT₇ Antagonists in Animal Models.
Pytka K1, Partyka A2, Jastrzębska-Więsek M2, Siwek A3, Głuch-Lutwin M3, Mordyl B3, Kazek G1, Rapacz A1, Olczyk A4, Gałuszka A4, Błachuta M4, Waszkielewicz A5, Marona H5, Sapa J1, Filipek B1, Wesołowska A2. PLoS One. 2015 Nov 10;10(11):e0142499. doi: 10.1371/journal.pone.0142499. eCollection 2015.
The aim of this study was to further characterize pharmacological properties of two phenylpiperazine derivatives: 1-{2-[2-(2,6-dimethlphenoxy)ethoxy]ethyl}-4-(2-methoxyphenyl)piperazynine hydrochloride (HBK-14) and 2-[2-(2-chloro-6-methylphenoxy)ethoxy]ethyl-4-(2- methoxyphenyl)piperazynine dihydrochloride (HBK-15) in radioligand binding and functional in vitro assays as well as in vivo models. Antidepressant-like properties were investigated in the forced swim test (FST) in mice and rats. Anxiolytic-like activity was evaluated in the four-plate test in mice and elevated plus maze test (EPM) in rats. Imipramine and escitalopram were used as reference drugs in the FST, and diazepam was used as a standard anxiolytic drug in animal models of anxiety. Our results indicate that HBK-14 and HBK-15 possess high or moderate affinity for serotonergic 5-HT2, adrenergic α1, and dopaminergic D2 receptors as well as being full 5-HT1A and 5-HT7 receptor antagonists.
3.Physicochemical characterization, fatty acid composition, and thermal analysis of Bertholletia excelsa HBK oil.
Pena Muniz MA1, Ferreira Dos Santos MN1, da Costa CE2, Morais L3, Lamarão ML1, Ribeiro-Costa RM1, Silva-Júnior JO1. Pharmacogn Mag. 2015 Jan-Mar;11(41):147-51. doi: 10.4103/0973-1296.149730.
The present study aimed at characterizing the oil extracted from Bertholletia excelsa H.B.K. almond, a native species from the Amazon region. Analytical methods used for oils and fats were employed through pharmacopoeia assays, AOCS (American Oil Chemists Society) standard methods as well as those recommended by ANVISA (National Health Surveillance Agency) such as acidity, peroxide value, saponification index, iodine value and refractive index, pH and relative density, and also thermoanalytical analyses (thermogravimetry, differential thermogravimetry and differential thermal analysis) as well as chromatographic analysis (gas chromatography). The characterization assessments of B. excelsa oil showed results indicating that the oil contains polyunsaturated fatty acids in large proportion. The termoanalytical tests indicated that B.excelsa oil showed thermal stability up to 220 °C, These results showed that the oil extracted from B. excelsa has acceptable characteristics and is of good quality.
4.Computer-assisted total knee arthroplasty using mini midvastus or medial parapatellar approach technique : A prospective, randomized, international multicentre trial.
Feczko P1, Engelmann L2, Arts JJ3, Campbell D4. BMC Musculoskelet Disord. 2016 Jan 13;17(1):19. doi: 10.1186/s12891-016-0872-7.
BACKGROUND: Despite the growing evidence in the literature there is still a lack of consensus regarding the use of minimally invasive surgical technique (MIS) in total knee arthroplasty (TKA).
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
