Arohynapene B
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| Category | Antibiotics |
| Catalog number | BBF-00092 |
| CAS | 154445-09-7 |
| Molecular Weight | 286.36 |
| Molecular Formula | C18H22O3 |
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Description
Arohynapene B is an anti-coccidial antibiotic produced by Pemcillum sp. FO-2295. It has no antibacterial activity.
Specification
| Synonyms | 5-(2-Hydroxymethyl-6,8-dimethyl-5,6,7,8-tetrahydronaphthalene)-2,4-pentadienoic acid; 2,4-Pentadienoic acid, 5-(5,6,7,8-tetrahydro-2-(hydroxymethyl)-6,8-dimethyl-1-naphthalenyl)- |
| IUPAC Name | (2E,4E)-5-[2-(hydroxymethyl)-6,8-dimethyl-5,6,7,8-tetrahydronaphthalen-1-yl]penta-2,4-dienoic acid |
| Canonical SMILES | CC1CC(C2=C(C1)C=CC(=C2C=CC=CC(=O)O)CO)C |
| InChI | InChI=1S/C18H22O3/c1-12-9-13(2)18-14(10-12)7-8-15(11-19)16(18)5-3-4-6-17(20)21/h3-8,12-13,19H,9-11H2,1-2H3,(H,20,21)/b5-3+,6-4+ |
| InChI Key | XVNDJROXVPBPBY-GGWOSOGESA-N |
Properties
| Appearance | Yellow Powder |
| Antibiotic Activity Spectrum | parasites |
| Boiling Point | 494.2°C at 760 mmHg |
| Density | 1.135 g/cm3 |
Reference Reading
1. Arohynapenes A and B, new anticoccidial agents produced by Penicillium sp. Taxonomy, fermentation, and structure elucidation
R Masuma, N Tabata, H Tomoda, K Haneda, Y Iwai, S Omura J Antibiot (Tokyo). 1994 Jan;47(1):46-53. doi: 10.7164/antibiotics.47.46.
Penicillium sp. FO-2295, a water isolate, was found to produce a series of new anticoccidial compounds. Two active compounds, designated arohynapenes A and B, were isolated from the fermentation broth of the producing strain by solvent extration and preparative HPLC. Arohynapene A was deduced to be (2E,4E)-5-(5-hydroxy-2,6,8-trimethyl-5,6,7,8-tetrahydronaphtale ne)-2,4- pentadienoic acid, and arohynapene B was (2E,4E)-5-(2-hydroxymethyl-6,8-dimethyl-5,6,7,8-tetrahydronapht alene)-2,4- pentadienoic acid. Arohynapenes inhibited the growth of Eimeria tenella in an in vitro assay using BHK-21 cells as a host. No schizont in the cells was observed at concentrations ranging above 35.0 microM and 7.0 microM for arohynapenes A and B, respectively.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
