Ascomatic acid
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| Category | Others |
| Catalog number | BBF-05658 |
| CAS | 93796-74-8 |
| Molecular Weight | 300.31 |
| Molecular Formula | C17H16O5 |
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Description
It is a new dibenzofuran and depside from the Lichen Bunodophoron patagonicum.
Specification
| Synonyms | 2-Dibenzofurancarboxylic acid, 3,7-dimethoxy-1,9-dimethyl-; 3,7-dimethoxy-1,9-dimethyldibenzofuran-2-carboxylic acid |
| IUPAC Name | 3,7-dimethoxy-1,9-dimethyldibenzo[b,d]furan-2-carboxylic acid |
Reference Reading
1. Stereoselective Synthesis and Application of Gibberellic Acid-Derived Aminodiols
Zein Alabdeen Khdar, Tam Minh Le, Zsuzsanna Schelz, István Zupkó, Zsolt Szakonyi Int J Mol Sci. 2022 Sep 8;23(18):10366. doi: 10.3390/ijms231810366.
A series of gibberellic acid-based aminodiols was designed and synthesized from commercially available gibberellic acid. Exposure of gibberellic acid to hydrochloric acid under reflux conditions resulted in aromatization followed by rearrangement to form allo-gibberic acid. The key intermediate, ethyl allo-gibberate, was prepared according to literature methods. Epoxidation of key intermediate and subsequent ring-opening of the corresponding epoxide with different nucleophiles resulted in N-substituted aminodiols. The regioselective ring closure of N-benzyl-substituted aminodiol with formaldehyde was also investigated. All aminodiol derivatives were well characterized using modern spectroscopic techniques and evaluated for their antiproliferative activity against a panel of human cancer cell lines. In addition, structure-activity relationships were examined by assessing substituent effects on the aminodiol systems. The results indicated that aminodiols containing aromatic rings on their nitrogen substituents displayed significant cytotoxic effects. Among these agents, N-naphthylmethyl-substituted aminodiols were found to be the most potent candidates in this series. One of these molecules exhibited a modest cancer selectivity determined by non-cancerous fibroblast cells. A docking study was also made to exploit the observed results.
2. Highly selective separation of eucalyptus hemicellulose by salicylic acid treatment with both aromatic and hydroxy acids
Baojuan Deng, Yajun Hou, Fei Wang, Yuqi Bao, Fanyan Zeng, Chengrong Qin, Chen Liang, Caoxing Huang, Jiliang Ma, Shuangquan Yao Bioresour Technol. 2022 Jul;355:127304. doi: 10.1016/j.biortech.2022.127304. Epub 2022 May 10.
Aromatic and hydroxyl acid treatments demonstrate their respective characteristics for the separation of lignocellulosic biomass. In this study, the effect of salicylic acid (SA-A) treatment on the separation of eucalyptus components with both aromatic and hydroxyl acid properties was analyzed. The optimal conditions were SA-A concentration 9.0%, reaction temperature 140 °C and time 75 min. The separation yield of xylose was 85.93%. The separation of cellulose and lignin was inhibited by SA-A treatment in contrast to the separation by glycolic acid and p-toluenesulfonic acid treatment. Moreover, SA-A treatment resulted in a larger fiber crystallinity index and higher thermal stability. The SA-A-treated samples contained lignin that was rich in β-O-4 and hydroxyl groups. The degradation and condensation of lignin was inhibited. The selectivity of aromatic acids for separating hemicellulose and protecting the lignin structure using hydroxy acids was demonstrated. Thus, new and efficient organic acid treatments can be developed.
3. Friedel-Crafts-Type Acylation and Amidation Reactions in Strong Brønsted Acid: Taming Superelectrophiles
Akinari Sumita, Tomohiko Ohwada Molecules. 2022 Sep 14;27(18):5984. doi: 10.3390/molecules27185984.
In this review, we discuss Friedel-Crafts-type aromatic amidation and acylation reactions, not exhaustively, but mainly based on our research results. The electrophilic species involved are isocyanate cation and acylium cation, respectively, and both have a common +C=O structure, which can be generated from carboxylic acid functionalities in a strong Brønsted acid. Carbamates substituted with methyl salicylate can be easily ionized to the isocyanate cation upon (di)protonation of the salicylate. Carboxylic acids can be used directly as a source of acylium cations. However, aminocarboxylic acids are inert in acidic media because two positively charged sites, ammonium and acylium cation, will be generated, resulting in energetically unfavorable charge-charge repulsion. Nevertheless, the aromatic acylation of aminocarboxylic acids can be achieved by using tailored phosphoric acid esters as Lewis bases to abrogate the charge-charge repulsion. Both examples tame the superelectrophilic character.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
