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Ashimycin A

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Ashimycin A
Category Enzyme inhibitors
Catalog number BBF-00104
CAS 123482-11-1
Molecular Weight 757.70
Molecular Formula C27H47N7O18

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Ashimycin A is an aminoglycoside antibiotic produced by Streptomyces griseus FT3-4. It has a broad-spectrum antibacterial activity, but is lower than streptomycin.

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  • Properties
  • Reference Reading
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Synonyms 2,4-Dicarbamimidamido-3,5,6-trihydroxycyclohexyl 2-C-carboxypentofuranosyl-(1->4)-2-deoxy-2-(methylamino)hexopyranosyl-(1->2)-5-deoxy-3-C-formylpentofuranoside
IUPAC Name 2-[6-[2-[2,4-bis(diaminomethylideneamino)-3,5,6-trihydroxycyclohexyl]oxy-4-formyl-4-hydroxy-5-methyloxolan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)-5-(methylamino)oxan-3-yl]oxy-3,4-dihydroxy-5-(hydroxymethyl)oxolane-3-carboxylic acid
Canonical SMILES CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)OC4C(C(C(O4)CO)O)(C(=O)O)O)O)NC)(C=O)O
InChI InChI=1S/C27H47N7O18/c1-6-26(45,5-37)19(21(47-6)50-17-10(34-25(30)31)12(38)9(33-24(28)29)13(39)15(17)41)52-20-11(32-2)14(40)16(7(3-35)48-20)51-23-27(46,22(43)44)18(42)8(4-36)49-23/h5-21,23,32,35-36,38-42,45-46H,3-4H2,1-2H3,(H,43,44)(H4,28,29,33)(H4,30,31,34)
InChI Key ILBIJYYHQHTSRJ-UHFFFAOYSA-N
Appearance White Powder
Antibiotic Activity Spectrum bacteria
Boiling Point 1155.5°C at 760 mmHg
Melting Point 150°C
Density 2.05 g/cm3
1. Ashimycins A and B, new streptomycin analogues
S Tohma, H Kondo, J Yokotsuka, J Iwamoto, G Matsuhashi, T Ito, H Seto J Antibiot (Tokyo). 1989 Aug;42(8):1205-12. doi: 10.7164/antibiotics.42.1205.
Detailed analysis of the fermentation broth of Streptomyces griseus strain FT3-4 resulted in the identification of two new streptomycin analogues named ashimycins A and B. Their structures have been determined by NMR spectral analysis and chemical degradations.

Bio Calculators

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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
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