Asparaginyl-asparagine
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| Category | Others |
| Catalog number | BBF-05466 |
| CAS | 58471-52-6 |
| Molecular Weight | 246.22 |
| Molecular Formula | C8H14N4O5 |
| Purity | ≥95% |
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Description
Asparaginyl-asparagine is a dipeptide composed of two L-asparagine. It is an incomplete breakdown product of protein digestion or protein catabolism. It has a role as a Mycoplasma genitalium metabolite.
Specification
| Synonyms | L-Asparagine, L-asparaginyl-; H-NN-OH; Asn-Asn; L-Asparaginyl-L-asparagine; Asparagylasparagin; L-Asn-L-Asn; (S)-4-Amino-2-((S)-2,4-diamino-4-oxobutanamido)-4-oxobutanoic acid |
| Sequence | H-Asn-Asn-OH |
| IUPAC Name | (2S)-4-amino-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]-4-oxobutanoic acid |
| Canonical SMILES | C(C(C(=O)NC(CC(=O)N)C(=O)O)N)C(=O)N |
| InChI | InChI=1S/C8H14N4O5/c9-3(1-5(10)13)7(15)12-4(8(16)17)2-6(11)14/h3-4H,1-2,9H2,(H2,10,13)(H2,11,14)(H,12,15)(H,16,17)/t3-,4-/m0/s1 |
| InChI Key | RJUHZPRQRQLCFL-IMJSIDKUSA-N |
Properties
| Appearance | Solid |
| Boiling Point | 789.2±60.0°C at 760 mmHg |
| Density | 1.5±0.1 g/cm3 |
| Solubility | Soluble in Water |
Reference Reading
1. H-Lys-Arg-Asn-Lys-Asn-Asn-OH is the minimal active structure of oxyntomodulin
C Carles-Bonnet, J Martinez, C Jarrousse, A Aumelas, H Niel, D Bataille Peptides. 1996;17(3):557-61. doi: 10.1016/0196-9781(96)00001-0.
Oxyntomodulin inhibits gastric acid secretion via its C-terminal octapeptide. Its minimal active structure was delineated by testing, on histamine-stimulated gastric acid secretion in the conscious rat, the inhibitory effect of octapeptide analogues, shortened either or both on their N- or C- terminus. The octapeptide may be simplified by deleting the two C-terminal amino acids while keeping its efficacy and the slope of the dose-response curve. Suppressing the first N-terminal amino acid dramatically decreased the activity. The nonprotected peptides are metabolized by aminopeptidases and endopeptidases. The increased potency of the N-acetylated forms is related, at least in part, with their protection against aminopeptidases.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
