Asparaginyl-lysine
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| Category | Others |
| Catalog number | BBF-05071 |
| CAS | 22677-58-3 |
| Molecular Weight | 260.29 |
| Molecular Formula | C10H20N4O4 |
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Description
Asparaginyl-Lysine is a dipeptide composed of asparagine and lysine.
Specification
| Synonyms | Asn-Lys; NK dipeptide |
| Sequence | H-DL-Asn-DL-Lys-OH |
| IUPAC Name | 6-amino-2-[(2,4-diamino-4-oxobutanoyl)amino]hexanoic acid |
| Canonical SMILES | C(CCN)CC(C(=O)O)NC(=O)C(CC(=O)N)N |
| InChI | InChI=1S/C10H20N4O4/c11-4-2-1-3-7(10(17)18)14-9(16)6(12)5-8(13)15/h6-7H,1-5,11-12H2,(H2,13,15)(H,14,16)(H,17,18) |
| InChI Key | QJMCHPGWFZZRID-UHFFFAOYSA-N |
Properties
| Boiling Point | 635.1±55.0°C at 760 mmHg |
| Density | 1.3±0.1 g/cm3 |
Reference Reading
1. An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library
C T Dooley, N N Chung, B C Wilkes, P W Schiller, J M Bidlack, G W Pasternak, R A Houghten Science. 1994 Dec 23;266(5193):2019-22. doi: 10.1126/science.7801131.
A synthetic combinatorial library containing 52,128,400 D-amino acid hexapeptides was used to identify a ligand for the mu opioid receptor. The peptide, Ac-rfwink-NH2, bears no resemblance to any known opioid peptide. Simulations using molecular dynamics, however, showed that three amino acid moieties have the same spatial orientation as the corresponding pharmacophoric groups of the opioid peptide PLO17. Ac-rfwink-NH2 was shown to be a potent agonist at the mu receptor and induced long-lasting analgesia in mice. Analgesia produced by intraperitoneally administered Ac-rfwink-NH2 was blocked by intracerebroventricular administration of naloxone, demonstrating that this peptide may cross the blood-brain barrier.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
