Asparaginyl-lysine

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Asparaginyl-lysine
Category Others
Catalog number BBF-05071
CAS 22677-58-3
Molecular Weight 260.29
Molecular Formula C10H20N4O4

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Description

Asparaginyl-Lysine is a dipeptide composed of asparagine and lysine.

Specification

Synonyms Asn-Lys; NK dipeptide
Sequence H-DL-Asn-DL-Lys-OH
IUPAC Name 6-amino-2-[(2,4-diamino-4-oxobutanoyl)amino]hexanoic acid
Canonical SMILES C(CCN)CC(C(=O)O)NC(=O)C(CC(=O)N)N
InChI InChI=1S/C10H20N4O4/c11-4-2-1-3-7(10(17)18)14-9(16)6(12)5-8(13)15/h6-7H,1-5,11-12H2,(H2,13,15)(H,14,16)(H,17,18)
InChI Key QJMCHPGWFZZRID-UHFFFAOYSA-N

Properties

Boiling Point 635.1±55.0°C at 760 mmHg
Density 1.3±0.1 g/cm3

Reference Reading

1. An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library
C T Dooley, N N Chung, B C Wilkes, P W Schiller, J M Bidlack, G W Pasternak, R A Houghten Science. 1994 Dec 23;266(5193):2019-22. doi: 10.1126/science.7801131.
A synthetic combinatorial library containing 52,128,400 D-amino acid hexapeptides was used to identify a ligand for the mu opioid receptor. The peptide, Ac-rfwink-NH2, bears no resemblance to any known opioid peptide. Simulations using molecular dynamics, however, showed that three amino acid moieties have the same spatial orientation as the corresponding pharmacophoric groups of the opioid peptide PLO17. Ac-rfwink-NH2 was shown to be a potent agonist at the mu receptor and induced long-lasting analgesia in mice. Analgesia produced by intraperitoneally administered Ac-rfwink-NH2 was blocked by intracerebroventricular administration of naloxone, demonstrating that this peptide may cross the blood-brain barrier.

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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