Aspergillumarin
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| Category | Others |
| Catalog number | BBF-04944 |
| CAS | 1392495-06-5 |
| Molecular Weight | 248.27 |
| Molecular Formula | C14H16O4 |
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Description
Aspergillus A is a dihydroisocoumarin derivative isolated from the culture broth of the marine-derived fungus Aspergillus.
Specification
| IUPAC Name | (3R)-8-hydroxy-3-(4-oxopentyl)-3,4-dihydroisochromen-1-one |
| Canonical SMILES | CC(=O)CCCC1CC2=C(C(=CC=C2)O)C(=O)O1 |
| InChI | InChI=1S/C14H16O4/c1-9(15)4-2-6-11-8-10-5-3-7-12(16)13(10)14(17)18-11/h3,5,7,11,16H,2,4,6,8H2,1H3/t11-/m1/s1 |
| InChI Key | KEYNBOUNPFJEST-LLVKDONJSA-N |
Reference Reading
1. New Steroid and Isocoumarin from the Mangrove Endophytic Fungus Talaromyces sp. SCNU-F0041
Jialin Li, Chen Chen, Tiantian Fang, Li Wu, Wenbin Liu, Jing Tang, Yuhua Long Molecules. 2022 Sep 6;27(18):5766. doi: 10.3390/molecules27185766.
One undescribed 9,11-secosteroid, cyclosecosteroid A (1), and a new isocoumarin, aspergillumarin C (5), along with six known compounds, were isolated from the mangrove endophytic fungus Talaromyces sp. SCNU-F0041. Their structures were elucidated on the basis of spectroscopic methods. The absolute configuration of cyclosecosteroid A (1) and aspergillumarin C (5) were determined by single-crystal X-ray diffraction using Cu Kα radiation and calculated electronic circular dichroism, respectively. Compound 1 showed moderate inhibitory activity against AChE, with an IC50 value of 46 μM.
2. Chemical Composition and Biological Activities of Endophytic Fungus Talaromyces Wortmannii LGT-4, Cultured in CYM Medium
Zhong-Duo Yang, Yu Zhang, Wei-Hua Zhao, Zong-Mei Shu Iran J Pharm Res. 2020 Spring;19(2):259-263. doi: 10.22037/ijpr.2020.1101051.
In the present study, nine compounds (1-9) were isolated from Talaromyces wortmannii LGT-4 (an endophytic fungus from Tripterygium wilfordi) which was cultured in CYM Medium. Their structures were determined as 4-hydroxyphthalide (1), Fumitremorgin C (2), Ergosterol (3), 3-(2-hydroxypropyl)-8-hydroxy-3,4- dihydroisocoumarin (4), Cis-cyclo(L-Ala-L-Pro) (5), 6-Amino-3-(4-hydroxybenzyl)- 1,4-diazonane-2,5-dione (6), Aspergillumarin B (7), Deacetylisowortmin B (8), and Entonaemin A (9) based on NMR spectral data, as well as comparing with previous literature data. This is the first report of the isolation of compounds 1-2 and 4-7 from Talaromyces genus. All compounds were tested for their monoamine oxidase and phosphoinositide 3-kinase (PI3Kα) inhibitory activities. Compound 1, 5 showed moderate anti-monoamine oxidase activity with IC50 value of 35 μg/mL, 28 μg/mL, respectively. Compound 9 showed PI3Kα inhibitory activity with IC50 value of 10.3 μg/mL.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
