AT 2433 A2
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-03213 |
| CAS | 102644-19-9 |
| Molecular Weight | 665.09 |
| Molecular Formula | C33H33ClN4O9 |
| Purity | >98% |
Online Inquiry
Description
AT 2433 A2 is an anti-tumor antibiotic produced by Actinomadura melliaura. It has activity against gram-positive bacteria.
Specification
| Synonyms | AT 2433-A2; AT2433-A2 |
| Storage | Store at -20°C |
| IUPAC Name | 3-[(2R,3R,4R,5S,6R)-6-[[(2S,4S,5S)-5-amino-4-hydroxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-methoxyoxan-2-yl]-5-chloro-13-methyl-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17,19,21-nonaene-12,14-dione |
| Canonical SMILES | CN1C(=O)C2=C3C4=C(C(=CC=C4)Cl)N(C3=C5C(=C2C1=O)C6=CC=CC=C6N5)C7C(C(C(C(O7)COC8CC(C(CO8)N)O)OC)O)O |
| InChI | InChI=1S/C33H33ClN4O9/c1-37-31(42)23-21-13-6-3-4-9-17(13)36-25(21)27-22(24(23)32(37)43)14-7-5-8-15(34)26(14)38(27)33-29(41)28(40)30(44-2)19(47-33)12-46-20-10-18(39)16(35)11-45-20/h3-9,16,18-20,28-30,33,36,39-41H,10-12,35H2,1-2H3/t16-,18-,19+,20-,28+,29+,30+,33+/m0/s1 |
| InChI Key | GZGADZPEYFVGGH-NWPISFAASA-N |
Properties
| Antibiotic Activity Spectrum | Gram-positive bacteria; Neoplastics (Tumor) |
| Boiling Point | 911.5±65.0°C at 760 mmHg |
| Density | 1.8±0.1 g/cm3 |
| Solubility | Soluble in DMSO |
Reference Reading
1. AT2433-A1, AT2433-A2, AT2433-B1 and AT2433-B2 novel antitumor compounds produced by Actinomadura melliaura. II. Structure determination
J Golik, T W Doyle, B Krishnan, G Dubay, J A Matson J Antibiot (Tokyo). 1989 Dec;42(12):1784-9. doi: 10.7164/antibiotics.42.1784.
The chemical structures of AT2433-A1 (2), AT2433-A2 (3), AT2433-B1 (4) and AT2433-B2 (5) were elucidated by degradation and spectroscopic studies. Compounds 2-5 are disaccharides closely related to rebeccamycin. The aglycone in 2 and 3 was determined to be 6-N-methyl-11-chloro-5H-indolo[2,3-a]pyrolo[3,4-c]carbazole and in 4 and 5 it was determined to be 6-N-methyl-5H-indolo[2,3-a]pyrolo[3,4-c]carbazole. Compounds 2 and 4 are 4-N"-methyl analogs of 3 and 5.
2. AT2433-A1, AT2433-A2, AT2433-B1, and AT2433-B2 novel antitumor antibiotic compounds produced by Actinomadura melliaura. Taxonomy, fermentation, isolation and biological properties
J A Matson, C Claridge, J A Bush, J Titus, W T Bradner, T W Doyle, A C Horan, M Patel J Antibiot (Tokyo). 1989 Nov;42(11):1547-55. doi: 10.7164/antibiotics.42.1547.
Compounds AT2433-A1 (A1), AT2433-A2 (A2), AT2433-B1 (B1), and AT2433-B2 (B2) were isolated from the cultured broth of Actinomadura melliaura sp. nov. (SCC 1655). Structurally these materials are closely related to rebeccamycin (1), an indolocarbazole antitumor antibiotic. A1, A2, B1, and B2 were active against Staphylococcus aureus A9537, Streptococcus faecalis A20688, Streptococcus faecium (ATCC 9790), Micrococcus lutea (ATCC 9341), Bacillus subtilis (ATCC 6633). A1 and B1 were active against P388 leukemia in mice.
Recommended Products
| BBF-05843 | Bacitracin | Inquiry |
| BBF-02576 | Pneumocandin B0 | Inquiry |
| BBF-03427 | Tubercidin | Inquiry |
| BBF-02582 | Polyporenic acid C | Inquiry |
| BBF-05781 | Emodepside | Inquiry |
| BBF-04621 | Artemisinin | Inquiry |
Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
