B-5354b
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| Category | Enzyme inhibitors |
| Catalog number | BBF-03220 |
| CAS | |
| Molecular Weight | 345.47 |
| Molecular Formula | C21H31NO3 |
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Description
B-5354b is a Sphingosine kinase (SPHK) inhibitor produced by SANK 71896. It has the activity of inhibiting SPHK with IC50 of 58 µmol/L.
Specification
| IUPAC Name | [(2E,7E)-Tetradeca-2,7-dienyl] 4-amino-3-hydroxybenzoate |
| Canonical SMILES | CCCCCCC=CCCCC=CCOC(=O)C1=CC(=C(C=C1)N)O |
| InChI | InChI=1S/C21H31NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25-21(24)18-14-15-19(22)20(23)17-18/h7-8,12-15,17,23H,2-6,9-11,16,22H2,1H3/b8-7+,13-12+ |
| InChI Key | WLYHWIFEWQXUPV-GEJAPMDVSA-N |
Properties
| Appearance | White Powder |
| Boiling Point | 511.9±50.0°C at 760 mmHg |
| Density | 1.0±0.1 g/cm3 |
Reference Reading
1. B-535a, b and c, new sphingosine kinase inhibitors, produced by a marine bacterium; taxonomy, fermentation, isolation, physico-chemical properties and structure determination
K Kono, M Tanaka, T Mizuno, K Kodama, T Ogita, T Kohama J Antibiot (Tokyo). 2000 Aug;53(8):753-8. doi: 10.7164/antibiotics.53.753.
In the course of our screening for inhibitors of sphingosine kinase, we found a series of active compounds in a culture broth of a novel marine bacterium, SANK 71896. The structures of the compounds, named B-5354a, b and c, were elucidated by a combination of spectroscopic analyses to be new esters of 4-amino-3-hydroxybenzoic acid with long-chain unsaturated alcohols. B-5354a, b and c inhibit sphingosine kinase activity with IC50 values of 21, 58 and 38 microm, respectively.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
