B-90063
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| Category | Enzyme inhibitors |
| Catalog number | BBF-03222 |
| CAS | |
| Molecular Weight | 582.69 |
| Molecular Formula | C28H30N4O6S2 |
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Description
B-90063 is an endothelin transferase (ECE) inhibitor produced by Blastobacter sp. SANK 71894. It has a strong inhibitory effect on human and rat ECE, with IC50 of 1.0 and 3.2 µmol/L, respectively.
Specification
| IUPAC Name | 5-[[6-formyl-4-oxo-2-(2-pentyl-1,3-oxazol-4-yl)-1H-pyridin-3-yl]disulfanyl]-4-oxo-6-(2-pentyl-1,3-oxazol-4-yl)-1H-pyridine-2-carbaldehyde |
| Canonical SMILES | CCCCCC1=NC(=CO1)C2=C(C(=O)C=C(N2)C=O)SSC3=C(NC(=CC3=O)C=O)C4=COC(=N4)CCCCC |
| InChI | InChI=1S/C28H30N4O6S2/c1-3-5-7-9-23-31-19(15-37-23)25-27(21(35)11-17(13-33)29-25)39-40-28-22(36)12-18(14-34)30-26(28)20-16-38-24(32-20)10-8-6-4-2/h11-16H,3-10H2,1-2H3,(H,29,35)(H,30,36) |
| InChI Key | XGYVRFWCPUXVES-UHFFFAOYSA-N |
Properties
| Appearance | Yellow Crystal Powder |
| Boiling Point | 760.0±60.0°C at 760 mmHg |
| Melting Point | 73-74°C |
| Density | 1.4±0.1 g/cm3 |
Reference Reading
1. B-90063, a novel endothelin converting enzyme inhibitor isolated from a new marine bacterium, Blastobacter sp. SANK 71894
S Takaishi, N Tuchiya, A Sato, T Negishi, Y Takamatsu, Y Matsushita, T Watanabe, Y Iijima, H Haruyama, T Kinoshita, M Tanaka, K Kodama J Antibiot (Tokyo). 1998 Sep;51(9):805-15. doi: 10.7164/antibiotics.51.805.
A novel endothelin-converting enzyme (ECE) inhibitor, B-90063, was isolated from the culture supernatant of the newly discovered marine bacterium Blastobacter sp. SANK 71894. Based on spectral analyses and chemical reactions, the structure of B-90063 was determined to be bis[6-formyl-4-hydroxy-2-(2'-n-pentyloxazol-4'-yl)-4-pyridon -3-yl]-disulfide (1a). Human and rat ECEs were inhibited more potently by B-90063, with respective IC50 values of 1.0 and 3.2 microM, than were other neutral endopeptidases such as NEP and type-I and -IV collagenases. B-90063 also inhibited the binding of ET-1 to rat ET(A) and bovine ET(B) receptors, though its antagonistic activities were weak. B-90063, thus, may abolish the physiological actions of endothelins through the ECE inhibitory and receptor antagonistic mechanisms.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
