Bacithrocin A
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Enzyme inhibitors |
| Catalog number | BBF-00251 |
| CAS | |
| Molecular Weight | 389.49 |
| Molecular Formula | C20H31N5O3 |
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Description
Bacithrocin A is produced by the strain of Bacillus laterosporus Laubach NR 2988. The ED50 of the four components A, B, C and D were 48, 84, 80, 124X10-6 mol/L, and the reference antipain was 13X10-6 mol/L, respectively.
Specification
| IUPAC Name | N-[(2S)-1-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-3-methylbutanamide |
| Canonical SMILES | CC(C)CC(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCN=C(N)N)C=O |
| InChI | InChI=1S/C20H31N5O3/c1-14(2)11-18(27)25-17(12-15-7-4-3-5-8-15)19(28)24-16(13-26)9-6-10-23-20(21)22/h3-5,7-8,13-14,16-17H,6,9-12H2,1-2H3,(H,24,28)(H,25,27)(H4,21,22,23)/t16?,17-/m0/s1 |
| InChI Key | JDLOASBKUAQMFJ-DJNXLDHESA-N |
Properties
| Appearance | Colorless Powder |
Reference Reading
1. Bacithrocins A, B and C, novel thrombin inhibitors
T Kamiyama, T Umino, Y Nakamura, Y Itezono, S Sawairi, T Satoh, K Yokose J Antibiot (Tokyo). 1994 Sep;47(9):959-68. doi: 10.7164/antibiotics.47.959.
Novel thrombin inhibitors, bacithrocins A, B and C, have been isolated from the culture broth of Bacillus laterosporus Laubach NR 2988. The structures of these inhibitors have been determined to be N-acyl-L-phenylalanyl-DL-arginal by the 2D-NMR experiments on their oxidation products and by amino acid analysis. Bacithrocin A inhibits thrombin, factor Xa and trypsin with IC50s of 48, 13 and 0.65 microM, respectively, which are similar to those of bacithrocins B and C. Bacithrocins prolong the clotting time induced by thrombin and factor Xa.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
