Bacithrocin B

Bacithrocin B

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Category Enzyme inhibitors
Catalog number BBF-00252
CAS
Molecular Weight 375.46
Molecular Formula C19H29N5O3

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Description

Bacithrocin B is produced by the strain of Bacillus laterosporus Laubach NR 2988. The ED50 of the four components A, B, C and D were 48, 84, 80, 124X10-6 mol/L, and the reference antipain was 13X10-6 mol/L, respectively.

Specification

IUPAC Name N-[(2S)-1-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-methylpropanamide
Canonical SMILES CC(C)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCN=C(N)N)C=O
InChI InChI=1S/C19H29N5O3/c1-13(2)17(26)24-16(11-14-7-4-3-5-8-14)18(27)23-15(12-25)9-6-10-22-19(20)21/h3-5,7-8,12-13,15-16H,6,9-11H2,1-2H3,(H,23,27)(H,24,26)(H4,20,21,22)/t15?,16-/m0/s1
InChI Key JRHGBVMMQSXTNA-LYKKTTPLSA-N

Properties

Appearance Colorless Powder

Reference Reading

1. Bacithrocins A, B and C, novel thrombin inhibitors
T Kamiyama, T Umino, Y Nakamura, Y Itezono, S Sawairi, T Satoh, K Yokose J Antibiot (Tokyo). 1994 Sep;47(9):959-68. doi: 10.7164/antibiotics.47.959.
Novel thrombin inhibitors, bacithrocins A, B and C, have been isolated from the culture broth of Bacillus laterosporus Laubach NR 2988. The structures of these inhibitors have been determined to be N-acyl-L-phenylalanyl-DL-arginal by the 2D-NMR experiments on their oxidation products and by amino acid analysis. Bacithrocin A inhibits thrombin, factor Xa and trypsin with IC50s of 48, 13 and 0.65 microM, respectively, which are similar to those of bacithrocins B and C. Bacithrocins prolong the clotting time induced by thrombin and factor Xa.

Bio Calculators

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
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