Bacithrocin B
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Enzyme inhibitors |
| Catalog number | BBF-00252 |
| CAS | |
| Molecular Weight | 375.46 |
| Molecular Formula | C19H29N5O3 |
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Description
Bacithrocin B is produced by the strain of Bacillus laterosporus Laubach NR 2988. The ED50 of the four components A, B, C and D were 48, 84, 80, 124X10-6 mol/L, and the reference antipain was 13X10-6 mol/L, respectively.
Specification
| IUPAC Name | N-[(2S)-1-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-methylpropanamide |
| Canonical SMILES | CC(C)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCN=C(N)N)C=O |
| InChI | InChI=1S/C19H29N5O3/c1-13(2)17(26)24-16(11-14-7-4-3-5-8-14)18(27)23-15(12-25)9-6-10-22-19(20)21/h3-5,7-8,12-13,15-16H,6,9-11H2,1-2H3,(H,23,27)(H,24,26)(H4,20,21,22)/t15?,16-/m0/s1 |
| InChI Key | JRHGBVMMQSXTNA-LYKKTTPLSA-N |
Properties
| Appearance | Colorless Powder |
Reference Reading
1. Bacithrocins A, B and C, novel thrombin inhibitors
T Kamiyama, T Umino, Y Nakamura, Y Itezono, S Sawairi, T Satoh, K Yokose J Antibiot (Tokyo). 1994 Sep;47(9):959-68. doi: 10.7164/antibiotics.47.959.
Novel thrombin inhibitors, bacithrocins A, B and C, have been isolated from the culture broth of Bacillus laterosporus Laubach NR 2988. The structures of these inhibitors have been determined to be N-acyl-L-phenylalanyl-DL-arginal by the 2D-NMR experiments on their oxidation products and by amino acid analysis. Bacithrocin A inhibits thrombin, factor Xa and trypsin with IC50s of 48, 13 and 0.65 microM, respectively, which are similar to those of bacithrocins B and C. Bacithrocins prolong the clotting time induced by thrombin and factor Xa.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
