BE-12406 A
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| Category | Antibiotics |
| Catalog number | BBF-03225 |
| CAS | 132417-96-0 |
| Molecular Weight | 468.45 |
| Molecular Formula | C25H24O9 |
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Description
BE-12406 A is an antitumor antibiotic produced by Streptomyces rutrersensis subsp. castelarensis. It has the activity of inhibiting murine P388 leukemia cells (IC50 is 0.8 µmol/L), and has the same activity against vincristine-doxorubicin resistant strains (P388/VCR) (IC50 is 0.2 µmol/L). It can inhibit the growth of S480 ascites carcinoma in mice.
Specification
| Synonyms | BE 12406A; 6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 12-((6-deoxy-alpha-L-mannopyranosyl)oxy)-1-hydroxy-10-methoxy-8-methyl- |
| IUPAC Name | 1-hydroxy-10-methoxy-8-methyl-12-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxynaphtho[1,2-c]isochromen-6-one |
| Canonical SMILES | CC1C(C(C(C(O1)OC2=C3C(=C4C(=C2)C5=C(C=C(C=C5OC)C)C(=O)O4)C=CC=C3O)O)O)O |
| InChI | InChI=1S/C25H24O9/c1-10-7-14-18(16(8-10)31-3)13-9-17(33-25-22(29)21(28)20(27)11(2)32-25)19-12(5-4-6-15(19)26)23(13)34-24(14)30/h4-9,11,20-22,25-29H,1-3H3/t11-,20-,21+,22+,25-/m0/s1 |
| InChI Key | FBBYGEDAGNDLMC-XNDKCNAWSA-N |
Properties
| Appearance | Light Yellow Crystal |
| Antibiotic Activity Spectrum | neoplastics (Tumor) |
| Boiling Point | 785.8±60.0°C at 760 mmHg |
| Density | 1.5±0.1 g/cm3 |
| Solubility | Soluble in Methanol, Water |
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
