BE-19412B
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| Category | Antibiotics |
| Catalog number | BBF-03230 |
| CAS | 173774-91-9 |
| Molecular Weight | 563.98 |
| Molecular Formula | C30H26ClNO8 |
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Description
BE-19412B is an antitumor antibiotic extracted from the culture medium of Streptomyces sp. A19412. It is toxic to mouse and human tumor cells such as P388, Ehrlich, DLD-1, PC-13, MKN-45 and Colon 26, with IC50 of 0.9-5.4 μg/mL, and can prolong the survival time of CDF1 mice with Ehrlich cancer.
Specification
| Synonyms | LS-94140 |
| IUPAC Name | 20-chloro-1,17-dihydroxy-3,19,21-trimethoxy-7,24-dimethyl-6-azahexacyclo[12.12.0.02,11.04,9.016,25.018,23]hexacosa-2(11),3,7,9,16,18,20,22,24-nonaene-5,15,26-trione |
| Canonical SMILES | CC1=CC2=CC3=C(C(=C2C(=O)N1)OC)C4(C(CC3)C(=O)C5=C(C6=C(C(=C(C=C6C(=C5C4=O)C)OC)Cl)OC)O)O |
| InChI | InChI=1S/C30H26ClNO8/c1-11-8-14-9-13-6-7-16-24(33)21-18(28(35)30(16,37)22(13)26(39-4)19(14)29(36)32-11)12(2)15-10-17(38-3)23(31)27(40-5)20(15)25(21)34/h8-10,16,34,37H,6-7H2,1-5H3,(H,32,36) |
| InChI Key | OTPGVWCTROIMAO-UHFFFAOYSA-N |
Properties
| Appearance | Dark Yellow Powder |
| Antibiotic Activity Spectrum | neoplastics (Tumor) |
Reference Reading
1. A new antitumor antibiotic, BE-19412A, produced by a streptomycete
M Tsukamoto, S Nakajima, H Arakawa, Y Sugiura, H Suzuki, M Hirayama, S Kamiya, Y Teshima, H Kondo, K Kojiri, H Suda J Antibiot (Tokyo). 1998 Oct;51(10):908-14. doi: 10.7164/antibiotics.51.908.
A new antitumor substance, designated BE-19412A, was isolated from the culture broth of Streptomyces sp. A19412. The active principle was extracted from the mycelium by methanol and purified by Silica gel and Sephadex LH-20 column chromatographies. BE-19412B was prepared by methylation of BE-19412A. BE-19412A and B exhibited cytotoxic activity against murine and human tumor cell lines. BE-19412A prolonged the survival of CDF1 mice bearing i.p. implanted Ehrlich carcinoma cells.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
