BE-32030C
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| Category | Antibiotics |
| Catalog number | BBF-03236 |
| CAS | 161589-11-3 |
| Molecular Weight | 814.02 |
| Molecular Formula | C43H67N5O10 |
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Description
BE-32030C is an antitumor antibiotic produced by Nocardia sp. A32030. It has inhibitory effect on the growth of P388, DLD-h PC-13 and MKN-45 tumor cells.
Specification
| Synonyms | BE-32030 C |
| IUPAC Name | [4-[(1-hydroxy-2-oxoazepan-3-yl)amino]-4-oxobutan-2-yl] 6-[[(Z)-hexadec-7-enoyl]-hydroxyamino]-2-[[2-(2-hydroxyphenyl)-4-methyl-5H-1,3-oxazole-4-carbonyl]amino]hexanoate |
| Canonical SMILES | CCCCCCCCC=CCCCCCC(=O)N(CCCCC(C(=O)OC(C)CC(=O)NC1CCCCN(C1=O)O)NC(=O)C2(COC(=N2)C3=CC=CC=C3O)C)O |
| InChI | InChI=1S/C43H67N5O10/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27-38(51)47(55)28-21-20-25-35(45-42(54)43(3)31-57-39(46-43)33-23-17-18-26-36(33)49)41(53)58-32(2)30-37(50)44-34-24-19-22-29-48(56)40(34)52/h11-12,17-18,23,26,32,34-35,49,55-56H,4-10,13-16,19-22,24-25,27-31H2,1-3H3,(H,44,50)(H,45,54)/b12-11- |
| InChI Key | IOEOSOYIFLFLDH-QXMHVHEDSA-N |
Properties
| Antibiotic Activity Spectrum | neoplastics (Tumor) |
| Density | 1.2±0.1 g/cm3 |
Reference Reading
1. BE-32030 A, B, C, D and E, new antitumor substances produced by Nocardia sp. A32030
M Tsukamoto, K Murooka, S Nakajima, S Abe, H Suzuki, K Hirano, H Kondo, K Kojiri, H Suda J Antibiot (Tokyo). 1997 Oct;50(10):815-21. doi: 10.7164/antibiotics.50.815.
New antitumor substances, designated BE-32030A, B, C, D and E, were isolated from the culture broth of Nocardia sp. A32030. The active principles were extracted from the mycelium by methanol and purified by Sephadex LH-20 and reversed-phase column chromatographies and finally by reversed-phase HPLC. BE-32030A, B, C, D and E inhibited the growth of P388 murine leukemia, DLD-1 human colon cancer, PC-13 human lung cancer and MKN-45 human stomach cancer cell lines.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
