BE-32030E

Name: BE-32030E
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Antibiotics
Catalog number	BBF-03238
CAS	161589-13-5
Molecular Weight	785.97
Molecular Formula	C41H63N5O10

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Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

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BE-32030E is an antitumor antibiotic produced by Nocardia sp. A32030. It has inhibitory effect on the growth of P388, DLD-h PC-13 and MKN-45 tumor cells.

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Synonyms	BE-32030 E
IUPAC Name	[4-[(1-hydroxy-2-oxoazepan-3-yl)amino]-4-oxobutan-2-yl] 2-[[2-(2-hydroxyphenyl)-4-methyl-5H-1,3-oxazole-4-carbonyl]amino]-6-[hydroxy-[(Z)-tetradec-5-enoyl]amino]hexanoate
Canonical SMILES	CCCCCCCCC=CCCCC(=O)N(CCCCC(C(=O)OC(C)CC(=O)NC1CCCCN(C1=O)O)NC(=O)C2(COC(=N2)C3=CC=CC=C3O)C)O
InChI	InChI=1S/C41H63N5O10/c1-4-5-6-7-8-9-10-11-12-13-14-25-36(49)45(53)26-19-18-23-33(43-40(52)41(3)29-55-37(44-41)31-21-15-16-24-34(31)47)39(51)56-30(2)28-35(48)42-32-22-17-20-27-46(54)38(32)50/h11-12,15-16,21,24,30,32-33,47,53-54H,4-10,13-14,17-20,22-23,25-29H2,1-3H3,(H,42,48)(H,43,52)/b12-11-
InChI Key	RQUNTWFQXNRDCK-QXMHVHEDSA-N

Antibiotic Activity Spectrum	neoplastics (Tumor)
Density	1.2±0.1 g/cm3

1. BE-32030 A, B, C, D and E, new antitumor substances produced by Nocardia sp. A32030

M Tsukamoto, K Murooka, S Nakajima, S Abe, H Suzuki, K Hirano, H Kondo, K Kojiri, H Suda J Antibiot (Tokyo). 1997 Oct;50(10):815-21. doi: 10.7164/antibiotics.50.815.

New antitumor substances, designated BE-32030A, B, C, D and E, were isolated from the culture broth of Nocardia sp. A32030. The active principles were extracted from the mycelium by methanol and purified by Sephadex LH-20 and reversed-phase column chromatographies and finally by reversed-phase HPLC. BE-32030A, B, C, D and E inhibited the growth of P388 murine leukemia, DLD-1 human colon cancer, PC-13 human lung cancer and MKN-45 human stomach cancer cell lines.

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BE-32030E

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