BE-32030E
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| Category | Antibiotics |
| Catalog number | BBF-03238 |
| CAS | 161589-13-5 |
| Molecular Weight | 785.97 |
| Molecular Formula | C41H63N5O10 |
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Description
BE-32030E is an antitumor antibiotic produced by Nocardia sp. A32030. It has inhibitory effect on the growth of P388, DLD-h PC-13 and MKN-45 tumor cells.
Specification
| Synonyms | BE-32030 E |
| IUPAC Name | [4-[(1-hydroxy-2-oxoazepan-3-yl)amino]-4-oxobutan-2-yl] 2-[[2-(2-hydroxyphenyl)-4-methyl-5H-1,3-oxazole-4-carbonyl]amino]-6-[hydroxy-[(Z)-tetradec-5-enoyl]amino]hexanoate |
| Canonical SMILES | CCCCCCCCC=CCCCC(=O)N(CCCCC(C(=O)OC(C)CC(=O)NC1CCCCN(C1=O)O)NC(=O)C2(COC(=N2)C3=CC=CC=C3O)C)O |
| InChI | InChI=1S/C41H63N5O10/c1-4-5-6-7-8-9-10-11-12-13-14-25-36(49)45(53)26-19-18-23-33(43-40(52)41(3)29-55-37(44-41)31-21-15-16-24-34(31)47)39(51)56-30(2)28-35(48)42-32-22-17-20-27-46(54)38(32)50/h11-12,15-16,21,24,30,32-33,47,53-54H,4-10,13-14,17-20,22-23,25-29H2,1-3H3,(H,42,48)(H,43,52)/b12-11- |
| InChI Key | RQUNTWFQXNRDCK-QXMHVHEDSA-N |
Properties
| Antibiotic Activity Spectrum | neoplastics (Tumor) |
| Density | 1.2±0.1 g/cm3 |
Reference Reading
1. BE-32030 A, B, C, D and E, new antitumor substances produced by Nocardia sp. A32030
M Tsukamoto, K Murooka, S Nakajima, S Abe, H Suzuki, K Hirano, H Kondo, K Kojiri, H Suda J Antibiot (Tokyo). 1997 Oct;50(10):815-21. doi: 10.7164/antibiotics.50.815.
New antitumor substances, designated BE-32030A, B, C, D and E, were isolated from the culture broth of Nocardia sp. A32030. The active principles were extracted from the mycelium by methanol and purified by Sephadex LH-20 and reversed-phase column chromatographies and finally by reversed-phase HPLC. BE-32030A, B, C, D and E inhibited the growth of P388 murine leukemia, DLD-1 human colon cancer, PC-13 human lung cancer and MKN-45 human stomach cancer cell lines.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
