BE-52440B
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| Category | Mycotoxins |
| Catalog number | BBF-03242 |
| CAS | 195051-23-1 |
| Molecular Weight | 670.68 |
| Molecular Formula | C33H34O13S |
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Description
BE-52400B is a cytotoxicity produced by Streptomyces sp. A52400. It has anti-proliferative effect on mouse tumor cell lines such as P388 leukemia and colon 26 colon and human tumor cell lines such as DLD1 (colon), PC-13 (lung), MKN-45 (stomach), etc., with IC50 of 1.1, 3.4, 0.69, 2.6, 2.9 μg/mL.
Specification
| IUPAC Name | methyl 2-[4a-[[9,10a-dihydroxy-3-(2-hydroxyethyl)-1-methyl-5,10-dioxo-3,4-dihydro-1H-benzo[g]isochromen-4a-yl]sulfanyl]-9,10a-dihydroxy-1-methyl-5,10-dioxo-3,4-dihydro-1H-benzo[g]isochromen-3-yl]acetate |
| Canonical SMILES | CC1C2(C(=O)C3=C(C=CC=C3O)C(=O)C2(CC(O1)CCO)SC45CC(OC(C4(C(=O)C6=C(C5=O)C=CC=C6O)O)C)CC(=O)OC)O |
| InChI | InChI=1S/C33H34O13S/c1-15-32(42)28(40)24-19(6-4-8-21(24)35)26(38)30(32,13-17(45-15)10-11-34)47-31-14-18(12-23(37)44-3)46-16(2)33(31,43)29(41)25-20(27(31)39)7-5-9-22(25)36/h4-9,15-18,34-36,42-43H,10-14H2,1-3H3 |
| InChI Key | FQVMROZBQLIJOI-UHFFFAOYSA-N |
Properties
| Antibiotic Activity Spectrum | neoplastics (Tumor) |
| Boiling Point | 922.2±65.0°C |
| Density | 1.59±0.1 g/cm3 |
Reference Reading
1. New cytotoxic agents, BE-52440A and B, produced by a streptomycete
M Tsukamoto, S Nakajima, K Murooka, M Naito, H Suzuki, M Hirayama, K Hirano, K Kojiri, H Suda J Antibiot (Tokyo). 2000 Jul;53(7):687-93. doi: 10.7164/antibiotics.53.687.
New cytotoxic substances, designated BE-52440A and B, were isolated from the mycelium of Streptomyces sp. A52440. The active principles were extracted from the mycelium by methanol and purified by silica gel column chromatography. BE-52440A and B exhibited cytotoxic activity against murine and human tumor cell lines.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
