Benastatin C
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| Category | Enzyme inhibitors |
| Catalog number | BBF-00284 |
| CAS | 150151-88-5 |
| Molecular Weight | 456.53 |
| Molecular Formula | C29H28O5 |
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Description
Benastatin C is produced by the strain of Streptomyces sp. MI 384-DF12. It can inhibit glutathione transferase (GST) activity.
Specification
| Synonyms | 13,13-Dimethyl-3-pentyl-1,7,9,11-tetrahydroxybenzo(a)naphthacen-8(13H)-one; Benzo(a)naphthacen-8(13H)-one, 1,7,9,11-tetrahydroxy-13,13-dimethyl-3-pentyl- |
| IUPAC Name | 1,7,9,11-tetrahydroxy-13,13-dimethyl-3-pentylbenzo[a]tetracen-8-one |
| Canonical SMILES | CCCCCC1=CC(=C2C(=C1)C=CC3=C(C4=C(C=C32)C(C5=C(C4=O)C(=CC(=C5)O)O)(C)C)O)O |
| InChI | InChI=1S/C29H28O5/c1-4-5-6-7-15-10-16-8-9-18-19(24(16)22(31)11-15)14-21-26(27(18)33)28(34)25-20(29(21,2)3)12-17(30)13-23(25)32/h8-14,30-33H,4-7H2,1-3H3 |
| InChI Key | QUNHGOCXEGJZAT-UHFFFAOYSA-N |
Properties
| Appearance | Yellow Powder |
| Melting Point | 214-216 °C |
Reference Reading
1. Benastatins C and D, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activities
T Aoyama, F Kojima, T Yamazaki, T Tatee, F Abe, Y Muraoka, H Naganawa, T Aoyagi, T Takeuchi J Antibiot (Tokyo). 1993 May;46(5):712-8. doi: 10.7164/antibiotics.46.712.
Benastatin C, a new member of the benastatins, has been isolated from the culture broth of Streptomyces sp. MI384-DF12. The structure of benastatin C was elucidated as 2-decarboxy-benastatin A by NMR studies. Benastatin D, 2-decarboxybenastatin B, was derived from benastatin B. Benastatins C and D showed inhibitory activities against human pi class glutathione S-transferase (GST pi) and excellent stimulatory activities on the murine lymphocyte blastogenesis in vitro.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
