Benzomalvin C
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| Category | Others |
| Catalog number | BBF-00631 |
| CAS | 157047-98-8 |
| Molecular Weight | 395.41 |
| Molecular Formula | C24H17N3O3 |
| Purity | >98% |
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Description
Benzomalvin C is produced by the strain of Penicillum sp. It is a neurokinin NK1 receptor antagonist and IDO inhibitor.
Specification
| Synonyms | 6'-methyl-3-phenyl-13'h-spiro[oxirane-2,7'-quinazolino[3,2-a][1,4]benzodiazepine]-5',13'(6'h)-dione; GK3542; GK 3542; GK-3542; benzomalvin C |
| Storage | -20° C |
| IUPAC Name | 6'-methyl-3-phenylspiro[oxirane-2,7'-quinazolino[3,2-a][1,4]benzodiazepine]-5',13'-dione |
| Canonical SMILES | CN1C(=O)C2=CC=CC=C2N3C(=O)C4=CC=CC=C4N=C3C15C(O5)C6=CC=CC=C6 |
| InChI | InChI=1S/C24H17N3O3/c1-26-21(28)17-12-6-8-14-19(17)27-22(29)16-11-5-7-13-18(16)25-23(27)24(26)20(30-24)15-9-3-2-4-10-15/h2-14,20H,1H3 |
| InChI Key | TWDKBDSVUUKABK-UHFFFAOYSA-N |
Properties
| Appearance | White Acicular Crystalline |
| Boiling Point | 646.2°C at 760 mmHg |
Reference Reading
1. Benzomalvins, new substance P inhibitors from a Penicillium sp
D M Sedlock, R Cooper, C J Barrow, H H Sun, A M Gillum J Antibiot (Tokyo) . 1994 May;47(5):515-22. doi: 10.7164/antibiotics.47.515.
In the course of screening microbial broths for neurokinin receptor antagonists, a series of new benzodiazepines, benzomalvins A (1), B (2) and C (3), has been isolated from the culture broth of a fungus identified as a Penicillium sp. Benzomalvin A (1) showed inhibitory activity against substance P with Ki values of 12, 42 and 43 microM at the guinea pig, rat and human neurokinin NK1 receptors, respectively. Benzomalvins B (2) and C (3) were only weakly active. The structures of these compounds were determined by spectroscopic methods including MS measurements and NMR analysis.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
